ArticleScientific reports2016
Structural basis for cytokinin production by LOG from Corynebacterium glutamicum.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Pseudomonas aeruginosa Relies on a Phosphoketolase to Support Anaerobic Survival Under Reductive Stress.Molecular microbiology · 2026Article
- Identification of a natural RcLOG1 allele linked to prickle development in Rose (Rosa spp.).Planta · 2025Article
- Coconut rhinoceros beetle, Oryctes rhinoceros (Coleoptera: Scarabaeidae), larval frass as plant fertilizer.Botanical studies · 2025Article
- Biochemical characterization of a unique cytokinin and nucleotide phosphoribohydrolase Lonely Guy protein fromBiochemistry and biophysics reports · 2024Article
- Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate.Nucleic acids research · 2023Article
- Comparative Genomics Reveals Genetic Diversity and Metabolic Potentials of the GenusMicrobiology spectrum · 2022Article
- Evolution of the Cytokinin Dehydrogenase (CKX) Domain.Journal of molecular evolution · 2021Article
- Biochemical and Structural Aspects of Cytokinin Biosynthesis and Degradation in Bacteria.Microorganisms · 2021Review
- The Hulks and the Deadpools of the Cytokinin Universe: A Dual Strategy for Cytokinin Production, Translocation, and Signal Transduction.Biomolecules · 2021Review
- (p)ppGpp-Dependent Regulation of the Nucleotide Hydrolase PpnN Confers Complement Resistance in Salmonella enterica Serovar Typhimurium.Infection and immunity · 2021Article
- CAPRIB: a user-friendly tool to study amino acid changes and selection for the exploration of intra-genus evolution.BMC genomics · 2020Article
- A cytokinin-activation enzyme-like gene improves grain yield under various field conditions in rice.Plant molecular biology · 2020Article
- Cytokinins Are Abundant and Widespread Among Insect Species.Plants (Basel, Switzerland) · 2020Article
- Exploring the Role of a Cytokinin-Activating Enzyme LONELY GUY in Unicellular MicroalgaFrontiers in plant science · 2020Article
- A LONELY GUY protein of Bordetella pertussis with unique features is related to oxidative stress.Scientific reports · 2019Article
- The Lonely Guy (LOG) Homologue SiRe_0427 from the Thermophilic ArchaeonApplied and environmental microbiology · 2019Article
- Review
- From plants to nematodes: Serratia grimesii BXF1 genome reveals an adaptation to the modulation of multi-species interactions.Microbial genomics · 2018Article
- Genomewide characterisation of the genetic diversity of carotenogenesis in bacteria of the order Sphingomonadales.Microbial genomics · 2018Article
- Structural basis for a novel type of cytokinin-activating protein.Scientific reports · 2017Article
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7 authors.
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Abstract
"Lonely guy" (LOG) has been identified as a cytokinin-producing enzyme in plants and plant-interacting fungi. The gene product of Cg2612 from the soil-dwelling bacterium Corynebacterium glutamicum was annotated as an LDC. However, the facts that C. glutamicum lacks an LDC and Cg2612 has high amino acid similarity with LOG proteins suggest that Cg2612 is possibly an LOG protein. To investigate the function of Cg2612, we determined its crystal structure at a resolution of 2.3 Å. Cg2612 functions as a dimer and shows an overall structure similar to other known LOGs, such as LOGs from Arabidopsis thaliana (AtLOG), Claviceps purpurea (CpLOG), and Mycobacterium marinum (MmLOG). Cg2612 also contains a "PGGXGTXXE" motif that contributes to the formation of an active site similar to other LOGs. Moreover, biochemical studies on Cg2612 revealed that the protein has phosphoribohydrolase activity but not LDC activity. Based on these structural and biochemical studies, we propose that Cg2612 is not an LDC family enzyme, but instead belongs to the LOG family. In addition, the prenyl-binding site of Cg2612 (CgLOG) comprised residues identical to those seen in AtLOG and CpLOG, albeit dissimilar to those in MmLOG. The work provides structural and functional implications for LOG-like proteins from other microorganisms.
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