ArticleNature communications2016
Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Antisense Oligonucleotide-MediatedAnimals : an open access journal from MDPI · 2026Article
- O-SNAP uncovers nanoscale chromatin remodeling in dedifferentiation and stress responses.Nature communications · 2026Article
- Derivation of Embryonic Stem Cells from an Endangered Cattle Breed via Somatic Cell Nuclear Transfer.Cells · 2026Article
- Cell Fusion in Reprogramming and Regeneration.Advances in experimental medicine and biology · 2026Review
- Rewriting cellular fate: epigenetic interventions in obesity and cellular programming.Molecular medicine (Cambridge, Mass.) · 2024Review
- Dissecting gene activation and chromatin remodeling dynamics in single human cells undergoing reprogramming.Cell reports · 2024Article
- Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation.Biochemical Society transactions · 2021Review
- Dynamic reversal of random X-Chromosome inactivation during iPSC reprogramming.Genome research · 2019Article
- Nuclear transplantation between allogeneic cells through topological reconnection of plasma membrane in a microfluidic system.Biomicrofluidics · 2019Article
- Recent Advances in Understanding the Reversal of Gene Silencing During X Chromosome Reactivation.Frontiers in cell and developmental biology · 2019Review
- Human X chromosome inactivation and reactivation: implications for cell reprogramming and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Dynamic Reorganization of Nucleosome Positioning in Somatic Cells after Transfer into Porcine Enucleated Oocytes.Stem cell reports · 2017Article
- Allele-specific analysis of cell fusion-mediated pluripotent reprograming reveals distinct and predictive susceptibilities of human X-linked genes to reactivation.Genome biology · 2017Article
- Characterization of X-Chromosome Gene Expression in Bovine Blastocysts Derived byFrontiers in genetics · 2017Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Erasure of epigenetic memory is required to convert somatic cells towards pluripotency. Reactivation of the inactive X chromosome (Xi) has been used to model epigenetic reprogramming in mouse, but human studies are hampered by Xi epigenetic instability and difficulties in tracking partially reprogrammed iPSCs. Here we use cell fusion to examine the earliest events in the reprogramming-induced Xi reactivation of human female fibroblasts. We show that a rapid and widespread loss of Xi-associated H3K27me3 and XIST occurs in fused cells and precedes the bi-allelic expression of selected Xi-genes by many heterokaryons (30-50%). After cell division, RNA-FISH and RNA-seq analyses confirm that Xi reactivation remains partial and that induction of human pluripotency-specific XACT transcripts is rare (1%). These data effectively separate pre- and post-mitotic events in reprogramming-induced Xi reactivation and reveal a complex hierarchy of epigenetic changes that are required to reactivate the genes on the human Xi chromosome.
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