ArticleScientific reports2016
Protective Effects of Arginine on Saccharomyces cerevisiae Against Ethanol Stress.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 121 citations in OpenAlex.
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- Transcriptomic shift in ethanol and amino acid metabolic genes regulated by Med15 during alcoholic fermentation.Microbial genomics · 2026Article
- 6PPD and 6PPD-Q Induce Mitochondrial Dysfunction inInternational journal of molecular sciences · 2026Article
- Development ofBiotechnology reports (Amsterdam, Netherlands) · 2026Article
- Multi-omics elucidation of resource allocation for enhanced ethanol production via precise glucose control in anaerobicSynthetic and systems biotechnology · 2026Article
- Sugar-induced cell death (SICD) inMicrobial cell (Graz, Austria) · 2026Article
- Reprogramming the EnvZ-OmpR two-component system confers ethanol tolerance in Escherichia coli by stabilizing the outer membrane and altering ferric homeostasis.PLoS genetics · 2025Article
- Analysis of disruptive action of electrical current on cell membrane integrity and modelling its antimicrobial activity.Archives of microbiology · 2025Article
- The Alleviating Effect of Arginine on Ethanol Stress inJournal of fungi (Basel, Switzerland) · 2025Article
- Regulation of Arginine Metabolism and Ethanol Tolerance inFood science & nutrition · 2025Article
- Transcriptional profiling reveals the effect of arginine on Actinobacillus succinogenes growth and fermentation.World journal of microbiology & biotechnology · 2025Article
- Comprehensive Analysis of the Proteome ofMicroorganisms · 2025Article
- Uga3 influences nitrogen metabolism inMicrobial cell (Graz, Austria) · 2025Article
- Proline Improves Pullulan Biosynthesis Under High Sugar Stress Condition.Microorganisms · 2024Article
- Overexpression of arginase geneSynthetic and systems biotechnology · 2024Article
- Different Nitrogen Consumption Patterns in Low Temperature Fermentations in the Wine YeastFoods (Basel, Switzerland) · 2024Article
- Imidazolium-based ionic liquids disrupt saccharomyces cerevisiae cell membrane integrity.Archives of microbiology · 2024Article
- Role of tailored sourdough fermentation in the flavor of wholegrain-oat bread.Current research in food science · 2024Article
- Contribution of trehalose to ethanol stress tolerance of Wickerhamomyces anomalus.BMC microbiology · 2023Article
- Transcriptomic profiling of the yeast Komagataella phaffii in response to environmental alkalinization.Microbial cell factories · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yeast cells are challenged by various environmental stresses in the process of industrial fermentation. As the currently main organism for bio-ethanol production, Saccharomyces cerevisiae suffers from ethanol stress. Some amino acids have been reported to be related to yeast tolerance to stresses. Here the relationship between arginine and yeast response to ethanol stress was investigated. Marked inhibitions of ethanol on cell growth, expression of genes involved in arginine biosynthesis and intracellular accumulation of arginine were observed. Furthermore, extracellular addition of arginine can abate the ethanol damage largely. To further confirm the protective effects of arginine on yeast cells, yeast strains with different levels of arginine content were constructed by overexpression of ARG4 involved in arginine biosynthesis or CAR1 encoding arginase. Intracellular arginine was increased by 18.9% or 13.1% respectively by overexpression of ARG4 or disruption of CAR1, which enhanced yeast tolerance to ethanol stress. Moreover, a 41.1% decrease of intracellular arginine was observed in CAR1 overexpressing strain, which made yeast cells keenly sensitive to ethanol. Further investigations indicated that arginine protected yeast cells from ethanol damage by maintaining the integrity of cell wall and cytoplasma membrane, stabilizing the morphology and function of organellae due to low ROS generation.
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