Evidence map›Paper›PMID 27507036›Full record

ArticleLipids in health and disease2016

Association of rs10811656 on 9P21.3 with the risk of coronary artery disease in a Chinese population.

Jianjun Yan, Jinmei Zeng, Zhiyong Xie, Dongchen Liu, Liansheng Wang, Zhong Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jianjun YanDepartment of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Jinmei ZengDepartment of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, East Campus, No. 222, Huanhu Xisan Road, Pudong New Area, Shanghai, 201306, China.
Zhiyong XieDepartment of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Dongchen LiuDepartment of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Liansheng WangDepartment of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. drlswang@njmu.edu.cn.
Zhong ChenDepartment of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, East Campus, No. 222, Huanhu Xisan Road, Pudong New Area, Shanghai, 201306, China. zhongchen7498@sina.com.cn.
Jiangsu Province Hospital · CNShanghai Sixth People's Hospital · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenome-wide association studies have reported that the 9p21.3 locus confers risk for coronary artery disease (CAD). However, it is not known whether rs10811656 is linked with CAD in a Chinese population. Thus, the purpose of this study was to investigate the potential association between rs10811656 and the risk of CAD in a Chinese population.

methodsWe conducted a hospital-based, case-control study with 251 CAD patients and 304 controls to examine the potential association of rs10811656 with CAD.

resultsThe frequencies of the TT genotypes in CAD cases were significantly different from those in controls (adjusted OR: 1.96, 95 % CI: 1.09-3.505, P = 0.024). Compared to controls, rs10811656 was significantly associated with the stable angina pectoris (adjusted OR: 1.42, 95 % CI: 1.06-1.90, P = 0.017), but not with acute coronary syndrome. There was also a highly significant association of rs10811656 with double-vessel and triple-vessel disease when patients were divided into subgroups based on the number of diseased vessels (adjusted OR: 1.68 and 1.60, 95 % CI: 1.14-2.44 and 1.10-2.33, P = 0.009 and 0.02, respectively).

conclusionOur results suggest that the rs10811656 locus might be associated with CAD in a Chinese Han population.

Indexed as

Genes, p16AgedAsian PeopleCase-Control StudiesChinaCoronary Artery DiseaseCyclin-Dependent Kinase Inhibitor p15Cyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p18FemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansLipidsMaleCDKN2A protein, humanCDKN2B protein, humanCyclin-Dependent Kinase Inhibitor p15Cyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p18LipidsAssociationCAD, coronary artery diseasers10811656SNP, single nucleotide polymorphismSusceptibility

Identifiers

PMID27507036
PMCPMC4979187
OpenAlexW2512007422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.