Evidence map›Paper›PMID 27506975›Full record

ArticleHormones & cancer2016

Global or Granulosa Cell-Specific Pten Mutations in Combination with Elevated FSH Levels Fail to Cause Ovarian Tumours in Mice.

Dannielle H Upton, Kirsty A Walters, Rachel E Allavena, Mark Jimenez, Reena Desai, David J Handelsman, Charles M Allan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hormones & cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dannielle H UptonANZAC Research Institute, University of Sydney, Concord Hospital, Sydney, NSW, 2139, Australia. dannielle.upton@sydney.edu.au.
Kirsty A WaltersANZAC Research Institute, University of Sydney, Concord Hospital, Sydney, NSW, 2139, Australia.
Rachel E AllavenaSchool of Veterinary Science, University of Queensland, QLD, Gatton, 4343, Australia.
Mark JimenezANZAC Research Institute, University of Sydney, Concord Hospital, Sydney, NSW, 2139, Australia.
Reena DesaiANZAC Research Institute, University of Sydney, Concord Hospital, Sydney, NSW, 2139, Australia.
David J HandelsmanANZAC Research Institute, University of Sydney, Concord Hospital, Sydney, NSW, 2139, Australia.
Charles M AllanANZAC Research Institute, University of Sydney, Concord Hospital, Sydney, NSW, 2139, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphatase and tensin homologue (PTEN) is a known tumour suppressor. To explore the role of Pten in ovarian tumorigenesis, we used transgenic (Tg) SOX2. Cre and AMH. Cre mouse models to direct global Pten haploinsufficiency (Pten

Indexed as

AnimalsFemaleFollicle Stimulating HormoneGranulosa CellsMammary Neoplasms, AnimalMiceMice, TransgenicMutationOrgan SizeOvarian NeoplasmsPTEN PhosphohydrolaseSOXB1 Transcription FactorsSurvival AnalysisUterine NeoplasmsFollicle Stimulating HormonePTEN PhosphohydrolasePten protein, mouseSox2 protein, mouseSOXB1 Transcription Factors

Identifiers

PMID27506975
PMCPMC10355859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.