ArticleBMC cancer2016
Optimizing the process of fertility preservation in pediatric female cancer patients - a multidisciplinary program.
Article in BMC cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Fertility preservation in rare ovarian malignancies: a decade-spanning systematic review of menstrual and reproductive outcomes.Cancer causes & control : CCC · 2025Pooled it
- Decoding cytarabine-induced damage in the prepubertal testis: A multi-omics atlas of ecosystem and inheritance.iScience · 2026Article
- Association of age, AMH, and gonadotropin dosing on IVF outcomes in fertility preservation cycles for patients less than 35 undergoing chemotherapeutic treatment: A retrospective cohort study.Journal of assisted reproduction and genetics · 2025Article
- Association of serum AMH levels with the number of oocytes retrieved in adolescent and young adult women undergoing controlled ovarian stimulation for fertility preservation.Archives of gynecology and obstetrics · 2025Article
- Clinical practice guideline for female fertility preservation.Frontiers in medicine · 2025Article
- Ethical, legal, social, and policy issues of ovarian tissue cryopreservation in prepubertal girls: a critical interpretive review.Journal of assisted reproduction and genetics · 2024Review
- Controlled ovarian stimulation in cancer patients under 18 years old; a case series.Journal of ovarian research · 2024Article
- Factors influencing perceived communication quality for successful fertility preservation counseling for adolescent and young adult cancer patients and their caregivers in Korea.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Consult and procedure incidence outcomes following establishment of a fertility preservation program for children with cancer.Journal of assisted reproduction and genetics · 2021Article
- Fertility-related services in pediatric oncology across the cancer continuum: a clinic overview.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Impact of legislation and public funding on oncofertility: a survey of Canadian, French and Moroccan pediatric hematologists/oncologists.BMC medical ethics · 2020Article
- Development of a Pediatric Fertility Preservation Program: A Report From the Pediatric Initiative Network of the Oncofertility Consortium.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2019Review
- How can we improve oncofertility care for patients? A systematic scoping review of current international practice and models of care.Human reproduction update · 2019Article
- Electrospun patterned porous scaffolds for the support of ovarian follicles growth: a feasibility study.Scientific reports · 2019Article
- Protective effects of mangafodipir against chemotherapy-induced ovarian damage in mice.Reproductive biology and endocrinology : RB&E · 2018Article
- Medical egg freezing: How cost and lack of insurance cover impact women and their families.Reproductive biomedicine & society online · 2018Article
- Medical egg freezing: the importance of a patient-centered approach to fertility preservation.Journal of assisted reproduction and genetics · 2018Article
- Prevalence and Predictors of Sperm Banking in Adolescents Newly Diagnosed With Cancer: Examination of Adolescent, Parent, and Provider Factors Influencing Fertility Preservation Outcomes.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2017Observational
- A transportation network for human ovarian tissue is indispensable to success for fertility preservation.Journal of assisted reproduction and genetics · 2017Review
- Fertility preservation issues in pediatric hematopoietic stem cell transplantation: practical approaches from the consensus of the Pediatric Diseases Working Party of the EBMT and the International BFM Study Group.Bone marrow transplantation · 2017Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrent evidence indicates sub-optimal incidence of fertility preservation (FP) in eligible patients. We present herein our designated multidisciplinary program for FP in pediatric and adolescent population and present our data on FP in female patients.
methodsPediatric patients (age 0-18) who were candidate for highly gonadotoxic treatments were referred to FP program for a multidisciplinary discussion and gonadal risk-assessment followed by either oocyte cryopreservation or ovarian cryopreservation (OCP) for female patients, and sperm banking for male patients. The OCP protocol consists of aspiration of oocytes from small antral follicles and in-vitro maturation followed by cryopreservation, as well as ovarian tissue cryopreservation.
resultsThe establishment of a designated FP program resulted in a significant increase in referral and subsequent FP procedures of all eligible patients. Sixty-two female patients were referred for FP discussion during a period of 36 months; 41 underwent OCP; 11 underwent oocyte cryopreservation and six were declined due to parental decision. The median age was 13.2y (range 18 months-18y). Thirty-two (51.6 %) were chemotherapy-naïve. Seventeen patients (27 %) had sarcoma, 16 patients (26 %) had acute leukemia. The mean number of mature oocytes that were eventually vitrified was significantly higher in chemotherapy-naïve patients compared with chemotherapy-exposed patients (mean 12 oocytes (1-42) versus 2 (0-7)).
conclusionMultidisciplinary programs that encompass experts of all relevant fields, skilled laboratory resources and a facilitated path appear to maximize the yield. We observed a considerable higher referral rates following launching a designated program and earlier OCP in chemo-naïve patients that culminated in a better fertility preservation procedure.
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