ArticleSurgery today2017
Association between the age and the development of colorectal cancer in patients with familial adenomatous polyposis: a multi-institutional study.
Article in Surgery today, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2024 for the clinical practice of hereditary colorectal cancer.International journal of clinical oncology · 2026Guideline
- Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.The British journal of surgery · 2024Guideline
- Colonoscopic surveillance without prophylactic colectomy in familial adenomatous polyposis: who are the appropriate candidates?Clinical endoscopy · 2026Article
- Article
- Intestinal transplantation in Familial Adenomatous Polyposis.Familial cancer · 2025Review
- Update on Surgical Management of FAP.Clinics in colon and rectal surgery · 2023Review
- Incidental cancer in colectomy specimens from patients with familial adenomatous polyposis: single centre experience and literature review.International journal of colorectal disease · 2023Review
- Updated Perspectives on the Diagnosis and Management of Familial Adenomatous Polyposis.The application of clinical genetics · 2023Review
- A case of early onset adenocarcinoma associated with colorectal polyposis with an unknown germline mutation.Surgical case reports · 2022Article
- Morphological Analyses of Colorectal Adenocarcinomas in Japanese Familial Adenomatous Polyposis Patients.Journal of the anus, rectum and colon · 2022Article
- Using genotype to assist clinical surveillance: a retrospective study of Chinese familial adenomatous polyposis patients.American journal of cancer research · 2022Article
- Mutational Analysis of a Familial Adenomatous Polyposis Pedigree with Bile Duct Polyp Phenotype.Canadian journal of gastroenterology & hepatology · 2021Article
- Relationship betweenAnnals of medicine and surgery (2012) · 2020Article
- Colonic Adenocarcinoma at Advanced Stage in Adolescence: Report of 2 Cases.Case reports in pathology · 2020Article
- Improved outcomes in Familial Adenomatous polyposis management. Results achieved in a single center over a 40-year period.Clinics (Sao Paulo, Brazil)Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the incidence of colorectal cancer among familial adenomatous polyposis (FAP) patients by phenotype using the latest modalities.
methodsWe collected data on 303 patients who underwent surgery for FAP at one of 23 institutions between 2000 and 2012. The incidence of colorectal cancer was investigated by phenotype.
resultsColorectal cancer was diagnosed in 115 (38.0 %) of the 303 patients. Overall, colorectal cancer with the attenuated, sparse, and profuse phenotypes was diagnosed at 30, 31, and 28 years of age, respectively, in 10 % of the patients and at 59, 48, and 41 years of age, respectively, in 50 % of the patients (P = 0.013). The patients with colorectal cancer were older than those without colorectal cancer for all phenotypes. The optimal cut-off age for predicting the development of colorectal cancer in the attenuated, sparse, and profuse phenotypes was 46, 31, and 27 years, respectively.
conclusionsPatients with profuse and sparse phenotypes should undergo prophylactic proctocolectomy before their mid-to-late 20 s. On the other hand, the timing and type of surgery for patients with attenuated FAP (AFAP) should be decided individually with reference to the colonoscopic findings.
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