ArticleScientific reports2016
A Functional Polymorphism (rs937283) in the MDM2 Promoter Region is Associated with Poor Prognosis of Retinoblastoma in Chinese Han Population.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and retinoblastoma susceptibility.Medicine · 2018Pooled it
- The Study of MDM2 rs937283 Variant and Cancer Susceptibility in a Central Chinese Population.Technology in cancer research & treatment · 2018Pooled it
- Association between tobacco substance usage and a missense mutation in the tumor suppressor gene P53 in the Saudi Arabian population.PloS one · 2021Trial
- Article
- TP53 mutations and MDM2 polymorphisms in breast and ovarian cancers: amelioration by drugs and natural compounds.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Review
- Genetic Variations inCancers · 2025Article
- Review
- Association of Murine Double Minute 2 polymorphisms with gastric cancer: A systematic review with meta-analysis.Biomedical reports · 2021Article
- Murine Double Minute 2 Gene (Saudi journal of biological sciences · 2021Article
- Associations ofJournal of clinical medicine · 2021Article
- Genetic Predisposition to Solid Pediatric Cancers.Frontiers in oncology · 2020Review
- The MDM2 rs937283 A > G variant significantly increases the risk of lung and gastric cancer in Chinese population.International journal of clinical oncology · 2018Article
- Altered Expression of Cell Cycle Regulators in Adult T-Cell Leukemia/ Lymphoma Patients.Reports of biochemistry & molecular biology · 2017Article
- The mouse double minute 2 309T>G polymorphism and retinoblastoma risk: A meta-analysis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of single nucleotide polymorphisms (SNPs) at MDM2 has been investigated in several cancer types. Three MDM2 SNPs(rs937283, rs2270744 and rs769412) have previously been suggested to be positively correlated with cancer. In this study, we aimed to explore the association of rs937283, rs2270744 and rs769412 polymorphisms with retinoblastoma (RB) risk, clinicopathological characteristics, and prognosis. Compared with wild-type genotype AA at rs937283, individuals carrying AG and GG genotype had a significantly increased risk for developing RB (OR = 1.86, 95% CI 1.13-3.08; OR = 2.48, 95% CI 1.10-5.62, respectively). RB patients with allele G at rs937283 were more susceptible to invasion and high tumor aggression (OR = 2.42, 95% CI 1.43-4.11; OR = 2.15, 95% CI 1.27-3.64, respectively). Kaplan-Meier curves and log-rank results revealed that RB patients harboring genotype GG and G allele at rs937283 had worse survival (P < 0.02 and P < 0.01, respectively). In addition, the A to G substitution at rs937283 significantly enhanced the transcription activity of the MDM2 gene in vitro. In vivo, we found that MDM2 mRNA and protein were overexpressed in individuals who carried the G allele at rs937283. This study suggested that the MDM2 rs937283 polymorphism is a novel functional SNP both in vitro and in vivo as well as a biomarker for poor prognosis in RB.
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