Evidence map›Paper›PMID 27506421›Full record

ArticleClinical and experimental immunology2016

The differential impact of natural killer (NK) cell education via KIR2DL3 and KIR3DL1 on CCL4 secretion in the context of in-vitro HIV infection.

I Lisovsky, G Isitman, A Tremblay-McLean, R Song, S DaFonseca, B Lebouchẻ, J-P Routy, J Bruneau, N F Bernard

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

I LisovskyResearch Institute of the McGill University Health Centre (MUHC), Montreal, Quebec, Canada.
G IsitmanResearch Institute of the McGill University Health Centre (MUHC), Montreal, Quebec, Canada.
A Tremblay-McLeanResearch Institute of the McGill University Health Centre (MUHC), Montreal, Quebec, Canada.
R SongResearch Institute of the McGill University Health Centre (MUHC), Montreal, Quebec, Canada.
S DaFonsecaResearch Institute of the McGill University Health Centre (MUHC), Montreal, Quebec, Canada.
B LebouchẻResearch Institute of the McGill University Health Centre (MUHC), Montreal, Quebec, Canada.
J-P RoutyDivision of Experimental Medicine, McGill University, Montreal, Quebec, Canada.
J BruneauDepartment of Family Medicine, Université de Montréal, Montreal, Quebec, Canada.
N F BernardResearch Institute of the McGill University Health Centre (MUHC), Montreal, Quebec, Canada.
McGill University · CAMcGill University Health Centre · CACentre Hospitalier de l’Université de Montréal · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carriage of certain inhibitory natural killer (NK) cell receptor (iNKR)/HLA ligand pairs is associated with protection from infection and slow time to AIDS implicating NK cells in HIV control. NK cells acquire functional potential through education, which requires the engagement of iNKRs by their human leucocyte antigen (HLA) ligands. HIV infection down-regulates cell surface HLA-A/B, but not HLA-C/E. We investigated how NK cell populations expressing combinations of the iNKRs NKG2A, KIR2DL3 (2DL3) and KIR3DL1 (3DL1) responded to autologous HIV infected CD4 (iCD4) cells. Purified NK cells from HIV-uninfected individuals were stimulated with autologous HIV iCD4 or uninfected CD4 T cells. Using flow cytometry we gated on each of the 8 NKG2A

Indexed as

CD4-Positive T-LymphocytesCells, CulturedChemokine CCL4GenotypeHIV-1HIV InfectionsHLA AntigensHLA-C AntigensHomozygoteHumansKiller Cells, NaturalLeukocytes, MononuclearLymphocyte ActivationReceptors, KIR2DL3Receptors, KIR3DL1Chemokine CCL4HLA AntigensHLA-C AntigensKIR2DL3 protein, humanKIR3DL1 protein, humanReceptors, KIR2DL3Receptors, KIR3DL1HIVinnate-immune responsesKIR-HLANK cell educationNK cells

Identifiers

PMID27506421
PMCPMC5108064
OpenAlexW2538976141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.