ArticleScientific reports2016
Interaction of Staphylococcus aureus persister cells with the host when in a persister state and following awakening.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Bacterial strategies for surviving antibiotics during urinary tract infection: could uropathogenic Escherichia coli be persisters?Nature reviews. Urology · 2026Review
- Antibiotic exposure and recovery of persister states influence virulence phenotypes in Pseudomonas aeruginosa.Archives of microbiology · 2026Article
- Salmonella enterica persister cells exhibit distinct susceptibility profiles following exposure to human serum and macrophages.PloS one · 2026Article
- Delayed host mortality and immune response upon infection withInfection and immunity · 2023Article
- Subversion of the Complement System by Pseudomonas aeruginosa.Journal of bacteriology · 2023Review
- Article
- Immune response modulation bybioRxiv : the preprint server for biology · 2023Article
- A Quantitative Survey of Bacterial Persistence in the Presence of Antibiotics: Towards Antipersister Antimicrobial Discovery.Antibiotics (Basel, Switzerland) · 2020Article
- Identification of essential oils with activity against stationary phase Staphylococcus aureus.BMC complementary medicine and therapies · 2020Article
- Pathogenesis and Clinical Relevance ofFrontiers in microbiology · 2020Review
- ResumptiveFrontiers in microbiology · 2019Article
- Persister Cells - a Plausible Outcome of Neutral Coevolutionary Drift.Scientific reports · 2018Article
- Implant infections: adhesion, biofilm formation and immune evasion.Nature reviews. Microbiology · 2018Review
- Slow and steady wins the race: an examination of bacterial persistence.AIMS microbiology · 2017Review
- The Agr Quorum Sensing System Represses Persister Formation through Regulation of Phenol Soluble Modulins inFrontiers in microbiology · 2017Article
- Convergence of Staphylococcus aureus Persister and Biofilm Research: Can Biofilms Be Defined as Communities of Adherent Persister Cells?PLoS pathogens · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persister cells, a tolerant cell sub-population, are commonly associated with chronic and recurrent infections. However, little is known about their ability to actually initiate or establish an infection, become virulent and cause pathogenicity within a host. Here we investigated whether Staphylococcus aureus persister cells initiate an infection and are recognized by macrophages, while in a persister cell status, and upon awakening due to exposure to cis-2-decenoic acid (cis-DA). Our results show that S. aureus persister cells are not able to initiate infections in A. thaliana and present significantly reduced virulence towards C. elegans compared to total populations. In contrast, awakened S. aureus persister cells are able to initiate infections in A. thaliana and in C. elegans albeit, with lower mortality than total population. Furthermore, exposure of S. aureus persister cells to cis-DA led to a loss of tolerance to ciprofloxacin, and an increase of the bacterial fluorescence to levels found in total population. In addition, macrophage engulfment of persister cells was significantly lower than engulfment of total population, both before and following awakening. Overall our findings indicate that upon awakening of a persister population the cells regain their ability to infect hosts despite the absence of an increased immune response.
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