ArticlePloS one2016
Comparative Transcriptome Profiling of Human Foreskin Fibroblasts Infected with the Sylvio and Y Strains of Trypanosoma cruzi.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Coinfection by multipleMicrobiology and molecular biology reviews : MMBR · 2025Review
- Paracrine Signaling Mediated by the Cytosolic Tryparedoxin Peroxidase ofPathogens (Basel, Switzerland) · 2024Article
- Differential cardiomyocyte transcriptomic remodeling during in vitro Trypanosoma cruzi infection using laboratory strains provides implications on pathogenic host responses.Tropical medicine and health · 2023Article
- High growth hormone serum partially protects mice against Trypanosoma cruzi infection.FEBS open bio · 2023Article
- Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations.Parasites & vectors · 2023Article
- Article
- Different Transcriptomic Response toFrontiers in cellular and infection microbiology · 2022Article
- Central role of metabolism in Trypanosoma cruzi tropism and Chagas disease pathogenesis.Current opinion in microbiology · 2021Review
- Transcriptional Studies onFrontiers in cellular and infection microbiology · 2021Review
- The First Contact of Human Dendritic Cells WithFrontiers in immunology · 2021Article
- Modulation of the Host Nuclear Compartment byFrontiers in cellular and infection microbiology · 2021Article
- Transcriptional remodeling during metacyclogenesis inVirulence · 2020Article
- Article
- Transcriptome analysis of alternative splicing in the pathogen life cycle in human foreskin fibroblasts infected with Trypanosoma cruzi.Scientific reports · 2020Article
- Gene expression network analyses during infection with virulent and avirulent Trypanosoma cruzi strains unveil a role for fibroblasts in neutrophil recruitment and activation.PLoS pathogens · 2020Article
- Slight temperature changes cause rapid transcriptomic responses in Trypanosoma cruzi metacyclic trypomastigotes.Parasites & vectors · 2020Article
- Transcriptomic changes across the life cycle ofPeerJ · 2020Article
- Article
- Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection.PLoS pathogens · 2017Article
- Trypanosoma cruzi specific mRNA amplification by in vitro transcription improves parasite transcriptomics in host-parasite RNA mixtures.BMC genomics · 2017Article
Corrections and comments
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3 authors.
Funding
Abstract
Trypanosoma cruzi, the causative agent of Chagas Disease, is phylogeneticaly distributed into nearly identical genetic strains which show divergent clinical presentations including differences in rates of cardiomyopathy in humans, different vector species and transmission cycles, differential congenital transmission in a mouse model, and differing immune and heart inflammation response in dogs. The population structure of these strains divides into two groups, which are geographically and clinically distinct. The aim of this study was to compare the transcriptome of two strains of T. cruzi, Sylvio vs. Y, to identify differences in expression that could account for clinical and biochemical differences. We collected and sequenced RNA from T. cruzi-infected and control Human Foreskin Fibroblasts at three timepoints. Differential expression analysis identified gene expression different timepoints in Sylvio infections, and between Sylvio and Y infections in both parasite and host. The Sylvio strain parasite and the host response to Sylvio infection largely mirrored the host-pathogen interaction seen in our previous Y strain work. IL-8 was more highly expressed in Sylvio-infected HFFs than in Y-infected HFFs.
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