Evidence map›Paper›PMID 27505356›Full record

ArticleNanotechnology2016

Simultaneous cytosolic delivery of a chemotherapeutic and siRNA using nanoparticle-stabilized nanocapsules.

Joseph Hardie, Ying Jiang, Emily R Tetrault, Phaedra C Ghazi, Gulen Yesilbag Tonga, Michelle E Farkas, Vincent M Rotello

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Polymer-mediated gene therapy: Recent advances and merging of delivery techniques.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Joseph HardieDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant St, Amherst, MA 01003, USA.
Ying JiangDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant St, Amherst, MA 01003, USA.
Emily R TetraultDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant St, Amherst, MA 01003, USA.
Phaedra C GhaziDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant St, Amherst, MA 01003, USA.
Gulen Yesilbag TongaDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant St, Amherst, MA 01003, USA.
Michelle E FarkasDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant St, Amherst, MA 01003, USA.ORCID 0000-0001-5824-1243
Vincent M RotelloDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant St, Amherst, MA 01003, USA.
University of Massachusetts Amherst · US

Funding

CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING GRANTST32GM008515 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THOMPSON, LYNMARIE K. · 1995 to 2020
$4.3M
Recognition and Presentation of Alpha Helices using Nanoparticle ReceptorsR01GM077173 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTELLO, VINCENT M. · 2007 to 2018
$3.7M
NIGMS NIH HHS R01 GM077173NIGMS NIH HHS T32 GM008515
6 · The paper itself

Abstract

We report on nanoparticle-stabilized capsules (NPSCs) as a platform for the co-delivery of survivin-targeted siRNA and tamoxifen. These capsules feature an inner oil core that provides a carrier for tamoxifen, and is coated on the surface with positively charged nanoparticles self-assembled with siRNA. The multifaceted chemical nature of the NPSC system enables the simultaneous delivery of both payloads directly into the cytosol in vitro. The NPSC co-delivery of tamoxifen and survivin-targeted siRNA into breast cancer cells disables the pathways that inhibit apoptosis, resulting in enhanced breast cell death.

Indexed as

NanoparticlesCytosolInhibitor of Apoptosis ProteinsNanocapsulesRNA, Small InterferingInhibitor of Apoptosis ProteinsNanocapsulesRNA, Small Interfering

Identifiers

PMID27505356
PMCPMC5011398
OpenAlexW2485784053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.