ArticlePLoS medicine2016
Core Outcomes for Colorectal Cancer Surgery: A Consensus Study.
Article in PLoS medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03351959 (Complete Pathologic Response Rectal Cancers EYSAC.1 Study), which is not on this map. Cited by 62 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Complete Pathologic Response Rectal Cancers EYSAC.1 Study
Who cites it
62 citing papers in PubMed, 10 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Medical students' evaluation of digital problem-based learning: a mixed-methods systematic review.BMC medical education · 2025Pooled it
- Anorectal malformation and outcome review (ARMOUR) project: a systematic review for the outcomes reported in patients with an anorectal malformation.BMJ paediatrics open · 2025Pooled it
- Relative efficacy of prehabilitation interventions and their components: systematic review with network and component network meta-analyses of randomised controlled trials.BMJ (Clinical research ed.) · 2025Pooled it
- A systematic review of oncosurgical and quality of life outcomes following pelvic exenteration for locally advanced and recurrent rectal cancer.Annals of the Royal College of Surgeons of England · 2025Pooled it
- Systematic review and meta-analysis of randomized controlled trials evaluating the effect of the level of ligation of inferior mesenteric artery on functional outcomes in rectal cancer surgery.International journal of colorectal disease · 2022Pooled it
- Global guidelines for emergency general surgery: systematic review and Delphi prioritization process.BJS open · 2022Pooled it
- Measurement of patient-reported outcomes after laparoscopic cholecystectomy: a systematic review.Surgical endoscopy · 2019Pooled it
- Guideline
- Systematic review of outcomes following pelvic exenteration for the treatment of primary and recurrent locally advanced rectal cancer.Techniques in coloproctology · 2018Pooled it
- Prognostic factors for return to work and work disability among colorectal cancer survivors; A systematic review.PloS one · 2018Pooled it
- Preoperative Weight Loss in Patients With Excess Weight and Colorectal Cancer: The CARE Feasibility Randomized Clinical Trial.JAMA network open · 2025Trial
- Quality-of-life outcomes in older patients with early-stage rectal cancer receiving organ-preserving treatment with hypofractionated short-course radiotherapy followed by transanal endoscopic microsurgery (TREC): non-randomised registry of patients unsuitable for total mesorectal excision.The lancet. Healthy longevity · 2022Trial
- Conservative treatment for uncomplicated appendicitis in children: the CONTRACT feasibility study, including feasibility RCT.Health technology assessment (Winchester, England) · 2021Trial
- Trial
- Trial
- Single-port robotic colorectal surgery: a scoping review of outcome reporting and future directions for standardisation.Journal of robotic surgery · 2026Article
- Development of a CORe outcome set for clinical trials of RECTal cancer treatment: protocol for the CORRECT initiative.BMJ open · 2026Article
- Patient Experiences and Expectations Regarding Erectile Dysfunction Education Prior to Rectal Cancer Surgery: A Qualitative Study.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026Article
- Article
- The lncrnas: innovative multifunctional players of drug resistance in colorectal cancer.Cancer cell international · 2025Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 10 institutions in 1 country.
Funding
Abstract
backgroundColorectal cancer (CRC) is a major cause of worldwide morbidity and mortality. Surgical treatment is common, and there is a great need to improve the delivery of such care. The gold standard for evaluating surgery is within well-designed randomized controlled trials (RCTs); however, the impact of RCTs is diminished by a lack of coordinated outcome measurement and reporting. A solution to these issues is to develop an agreed standard "core" set of outcomes to be measured in all trials to facilitate cross-study comparisons, meta-analysis, and minimize outcome reporting bias. This study defines a core outcome set for CRC surgery. METHODS AND
findingsThe scope of this COS includes clinical effectiveness trials of surgical interventions for colorectal cancer. Excluded were nonsurgical oncological interventions. Potential outcomes of importance to patients and professionals were identified through systematic literature reviews and patient interviews. All outcomes were transcribed verbatim and categorized into domains by two independent researchers. This informed a questionnaire survey that asked stakeholders (patients and professionals) from United Kingdom CRC centers to rate the importance of each domain. Respondents were resurveyed following group feedback (Delphi methods). Outcomes rated as less important were discarded after each survey round according to predefined criteria, and remaining outcomes were considered at three consensus meetings; two involving international professionals and a separate one with patients. A modified nominal group technique was used to gain the final consensus. Data sources identified 1,216 outcomes of CRC surgery that informed a 91 domain questionnaire. First round questionnaires were returned from 63 out of 81 (78%) centers, including 90 professionals, and 97 out of 267 (35%) patients. Second round response rates were high for all stakeholders (>80%). Analysis of responses lead to 45 and 23 outcome domains being retained after the first and second surveys, respectively. Consensus meetings generated agreement on a 12 domain COS. This constituted five perioperative outcome domains (including anastomotic leak), four quality of life outcome domains (including fecal urgency and incontinence), and three oncological outcome domains (including long-term survival).
conclusionThis study used robust consensus methodology to develop a core outcome set for use in colorectal cancer surgical trials. It is now necessary to validate the use of this set in research practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.