ArticlePloS one2016
The Grapevine Uncharacterized Intrinsic Protein 1 (VvXIP1) Is Regulated by Drought Stress and Transports Glycerol, Hydrogen Peroxide, Heavy Metals but Not Water.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 51 citations in OpenAlex.
- OsPIP2;4 aquaporin water channel primarily expressed in roots of rice mediates both water and nonselective NaScientific reports · 2025Article
- Analysis ofPlants (Basel, Switzerland) · 2023Article
- Genomic diversity of aquaporins across genus Oryza provides a rich genetic resource for development of climate resilient rice cultivars.BMC plant biology · 2023Article
- Article
- FungalBiomolecules · 2021Article
- Arbuscular Mycorrhiza-Mediated Regulation of Polyamines and Aquaporins During Abiotic Stress: Deep Insights on the Recondite Players.Frontiers in plant science · 2021Review
- Sweet Cherry (International journal of molecular sciences · 2020Article
- Molecular and Functional Characterization of Grapevine NIPs through Heterologous Expression inInternational journal of molecular sciences · 2020Article
- Human Aquaporin-5 Facilitates Hydrogen Peroxide Permeation Affecting Adaption to Oxidative Stress and Cancer Cell Migration.Cancers · 2019Article
- Overexpression of X Intrinsic Protein 1;1 inPlant direct · 2019Article
- Genome-wide comparison reveals divergence of cassava and rubber aquaporin family genes after the recent whole-genome duplication.BMC genomics · 2019Article
- Plant and Mammal Aquaporins: Same but Different.International journal of molecular sciences · 2018Review
- Regulation of aquaporins in plants under stress.Biological research · 2018Review
- Article
- Analysis of aquaporins in Brassicaceae species reveals high-level of conservation and dynamic role against biotic and abiotic stress in canola.Scientific reports · 2017Article
- Symbiosis With Rhizophagus irregularis Improves Grapevine Rootstock Performances Under Water Deficit Conditions.Physiologia plantarumArticle
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A MIP (Major Intrinsic Protein) subfamily called Uncharacterized Intrinsic Proteins (XIP) was recently described in several fungi and eudicot plants. In this work, we cloned a XIP from grapevine, VvXIP1, and agrobacterium-mediated transformation studies in Nicotiana benthamiana revealed that the encoded aquaporin shows a preferential localization at the endoplasmic reticulum membrane. Stopped-flow spectrometry in vesicles from the aqy-null yeast strain YSH1172 overexpressing VvXIP1 showed that VvXIP1 is unable to transport water but is permeable to glycerol. Functional studies with the ROS sensitive probe CM-H2DCFDA in intact transformed yeasts showed that VvXIP1 is also able to permeate hydrogen peroxide (H2O2). Drop test growth assays showed that besides glycerol and H2O2, VvXIP1 also transports boric acid, copper, arsenic and nickel. Furthermore, we found that VvXIP1 transcripts were abundant in grapevine leaves from field grown plants and strongly repressed after the imposition of severe water-deficit conditions in potted vines. The observed downregulation of VvXIP1 expression in cultured grape cells in response to ABA and salt, together with the increased sensitivity to osmotic stress displayed by the aqy-null yeast overexpressing VvXIP1, corroborates the role of VvXIP1 in osmotic regulation besides its involvement in H2O2 transport and metal homeostasis.
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