Evidence map›Paper›PMID 27504852›Full record

ArticleThe Journal of clinical endocrinology and metabolism2016

Insulinoma Due to Multiple Pancreatic Microadenoma Localized by Multimodal Imaging.

Bruna Babic, Xavier Keutgen, Pavel Nockel, Markke Miettinen, Corina Millo, Peter Herscovitch, Dhaval Patel, Naris Nilubol, Craig Cochran, Phillip Gorden and 1 more

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Bruna BabicEndocrine Oncology Branch (B.B., X.K., P.N., D.P., N.N., E.K.), and Laboratory of Pathology (M.M.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; PET Department (C.M., P.H.), National Institutes of Health Clinical Center, Bethesda, Maryland 20814; and National Institute of Diabetes and Digestive and Kidney Diseases (C.C., P.G.), National Institutes of Health, Bethesda, Maryland 20892.
Xavier KeutgenEndocrine Oncology Branch (B.B., X.K., P.N., D.P., N.N., E.K.), and Laboratory of Pathology (M.M.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; PET Department (C.M., P.H.), National Institutes of Health Clinical Center, Bethesda, Maryland 20814; and National Institute of Diabetes and Digestive and Kidney Diseases (C.C., P.G.), National Institutes of Health, Bethesda, Maryland 20892.
Pavel NockelEndocrine Oncology Branch (B.B., X.K., P.N., D.P., N.N., E.K.), and Laboratory of Pathology (M.M.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; PET Department (C.M., P.H.), National Institutes of Health Clinical Center, Bethesda, Maryland 20814; and National Institute of Diabetes and Digestive and Kidney Diseases (C.C., P.G.), National Institutes of Health, Bethesda, Maryland 20892.
Markke MiettinenEndocrine Oncology Branch (B.B., X.K., P.N., D.P., N.N., E.K.), and Laboratory of Pathology (M.M.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; PET Department (C.M., P.H.), National Institutes of Health Clinical Center, Bethesda, Maryland 20814; and National Institute of Diabetes and Digestive and Kidney Diseases (C.C., P.G.), National Institutes of Health, Bethesda, Maryland 20892.
Corina MilloEndocrine Oncology Branch (B.B., X.K., P.N., D.P., N.N., E.K.), and Laboratory of Pathology (M.M.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; PET Department (C.M., P.H.), National Institutes of Health Clinical Center, Bethesda, Maryland 20814; and National Institute of Diabetes and Digestive and Kidney Diseases (C.C., P.G.), National Institutes of Health, Bethesda, Maryland 20892.
Peter HerscovitchEndocrine Oncology Branch (B.B., X.K., P.N., D.P., N.N., E.K.), and Laboratory of Pathology (M.M.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; PET Department (C.M., P.H.), National Institutes of Health Clinical Center, Bethesda, Maryland 20814; and National Institute of Diabetes and Digestive and Kidney Diseases (C.C., P.G.), National Institutes of Health, Bethesda, Maryland 20892.
Dhaval PatelEndocrine Oncology Branch (B.B., X.K., P.N., D.P., N.N., E.K.), and Laboratory of Pathology (M.M.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; PET Department (C.M., P.H.), National Institutes of Health Clinical Center, Bethesda, Maryland 20814; and National Institute of Diabetes and Digestive and Kidney Diseases (C.C., P.G.), National Institutes of Health, Bethesda, Maryland 20892.
Naris NilubolEndocrine Oncology Branch (B.B., X.K., P.N., D.P., N.N., E.K.), and Laboratory of Pathology (M.M.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; PET Department (C.M., P.H.), National Institutes of Health Clinical Center, Bethesda, Maryland 20814; and National Institute of Diabetes and Digestive and Kidney Diseases (C.C., P.G.), National Institutes of Health, Bethesda, Maryland 20892.
Craig CochranEndocrine Oncology Branch (B.B., X.K., P.N., D.P., N.N., E.K.), and Laboratory of Pathology (M.M.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; PET Department (C.M., P.H.), National Institutes of Health Clinical Center, Bethesda, Maryland 20814; and National Institute of Diabetes and Digestive and Kidney Diseases (C.C., P.G.), National Institutes of Health, Bethesda, Maryland 20892.
Phillip GordenEndocrine Oncology Branch (B.B., X.K., P.N., D.P., N.N., E.K.), and Laboratory of Pathology (M.M.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; PET Department (C.M., P.H.), National Institutes of Health Clinical Center, Bethesda, Maryland 20814; and National Institute of Diabetes and Digestive and Kidney Diseases (C.C., P.G.), National Institutes of Health, Bethesda, Maryland 20892.
Electron KebebewEndocrine Oncology Branch (B.B., X.K., P.N., D.P., N.N., E.K.), and Laboratory of Pathology (M.M.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; PET Department (C.M., P.H.), National Institutes of Health Clinical Center, Bethesda, Maryland 20814; and National Institute of Diabetes and Digestive and Kidney Diseases (C.C., P.G.), National Institutes of Health, Bethesda, Maryland 20892.
National Institutes of Health · USNational Institutes of Health Clinical Center · USNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Genreal Surgical PathologyZIDBC011291 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MIETTINEN, MARKKU · 2010 to 2025
$30.3M
Studies of clinical endocrine tumorsZIADK047051 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GORDEN, PHILLIP · 2009 to 2018
$2.5M
6 · The paper itself

Abstract

contextInsulinomas are usually due to a solitary tumor, but they can be challenging to localize. CASE DESCRIPTION: A 66-year-old woman presented with a 1-year history of episodic neuroglycopenic hypoglycemia and was suspected of having an insulinoma. On a supervised fast, she was found to be hypoglycemic at 39 mg/dL, with an insulin of 40 μU/mL 26 hours into the fast and a proinsulin of 35 pmol/L. Contrast-enhanced computed tomography and magnetic resonance imaging did not localize a pancreatic lesion. Intra-arterial calcium stimulation testing showed a step-up of venous insulin levels at injection of the superior mesenteric artery and proximal and mid-splenic artery, and a

conclusionsMultiple microadenomas are a rare cause of hyperinsulinemic hypoglycemia and localization, and resection of these tumors may be facilitated by multimodal imaging.

Indexed as

AgedFemaleHumansInsulinomaMagnetic Resonance ImagingMultimodal ImagingPancreatectomyPancreatic NeoplasmsPositron Emission Tomography Computed Tomography

Identifiers

PMID27504852
PMCPMC5052346
OpenAlexW2521813741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.