Evidence map›Paper›PMID 27504821›Full record

ArticleThe Angle orthodontist2017

Orthodontically induced external apical root resorption in patients treated with fixed appliances vs removable aligners.

Alejandro Iglesias-Linares, Boris Sonnenberg, Beatriz Solano, Rosa-Maria Yañez-Vico, Enrique Solano, Steven J Lindauer, Carlos Flores-Mir

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Angle orthodontist, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07273552 (Efficacy of Root Torque Control in Adult Non-extraction Spacing Cases Treated With Directly 3D Printed Clear Aligners), which is not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07273552 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Root Torque Control in Adult Non-extraction Spacing Cases Treated With Directly 3D Printed Clear Aligners: a Cone Beam Computed Tomography Study

TypeinterventionalSponsorSuez Canal UniversityRan2025 to 2026Enrolled14ConditionsEffect of Direct Printed Aligners on Root TorqueArmsDirect printed aligners
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alejandro Iglesias-Linares
Boris Sonnenberg
Beatriz Solano
Rosa-Maria Yañez-Vico
Enrique Solano
Steven J Lindauer
Carlos Flores-Mir
Universidad de Sevilla · ESUniversidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine whether orthodontic treatment with removable aligners vs fixed orthodontic appliances is associated with a different frequency of orthodontically induced external apical root resorption (OIEARR) when genetic, radiographic, and clinical factors are accounted for. MATERIALS AND

methodsThree hundred seventy-two orthodontic patients treated with removable aligners (Invisalign) or fixed appliances were genetically screened for interleukin 1B gene (IL1B) (rs1143634), interleukin 1 receptor antagonist gene (IL1RN) (rs419598), and osteopontin gene (SPP1) (rs9138/rs11730582). Twelve clinical variables, potentially associated with OIEARR, were also considered. Subjects were divided according to the presence of radiographically determined OIEARR (>2 mm). The association between OIEARR and appliance type, and radiographic, clinical and genetic factors, was assessed using backward stepwise conditional logistic regression. Odds ratios (ORs) and 95% confidence intervals (CIs) were reported.

resultsReliability of the methods was adequate. Clinical case complexity (American Board of Orthodontics [ABO] Discrepancy Index) (OR: 1.032; 95% CI: 1.005-1.061; P = .021) and extent of incisor apical displacement in the sagittal plane (OR: 1.478; 95% CI: 1.285-1.699; P = .001) were associated with an increased OIEARR risk. After adjusting for associations between clinical/radiographic/genetic factors, there were no statistically significant differences with respect to OIEARR or type of orthodontic appliance used, whether removable aligners or fixed appliances (OR: 1.662; 95% CI: 0.945-2.924; P = .078). Only subjects homozygous for the T allele of IL1RN (rs419598) were more prone to OIEARR during orthodontic treatment (OR: 3.121; CI: 1.93-5.03; P < .001).

conclusionsA similar OIEARR predisposition was identified using either removable aligners (Invisalign) or fixed appliances.

Indexed as

Tooth ApexAdolescentAdultChildChromosomes, Human, Pair 2Chromosomes, Human, Pair 4FemaleGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansIncisorInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinLogistic ModelsMaleIL1B protein, humanIL1RN protein, humanInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinOsteopontinSPP1 protein, humanExternal apical root resorptionOrthodonticsRoot resorption

Identifiers

PMID27504821
PMCPMC8388604
OpenAlexW2508104454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.