ArticleeLife2016
Adaptive learning and decision-making under uncertainty by metaplastic synapses guided by a surprise detection system.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Adaptive reorganization of history encoding in the retrosplenial cortex supports flexible decision-making strategies.Neuron · 2026Article
- Duration between rewards controls the rate of behavioral and dopaminergic learning.Nature neuroscience · 2026Article
- A bio-inspired minimal model for non-stationary K-armed bandits.Biological cybernetics · 2026Article
- An Information-Theoretic Framework for Understanding Learning and Choice Under Uncertainty.Entropy (Basel, Switzerland) · 2025Article
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- Computational and Neural Evidence for Altered Fast and Slow Learning from Losses in Problem Gambling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dopamine transients encode reward prediction errors independent of learning rates.Cell reports · 2024Article
- Dopamine transients encode reward prediction errors independent of learning rates.bioRxiv : the preprint server for biology · 2024Article
- Discounting Future Reward in an Uncertain World.Decision (Washington, D.C.) · 2024Article
- Fast adaptation to rule switching using neuronal surprise.PLoS computational biology · 2024Article
- Two Determinants of Dynamic Adaptive Learning for Magnitudes and Probabilities.Open mind : discoveries in cognitive science · 2024Article
- Pupil diameter tracked during motor adaptation in humans.Journal of neurophysiology · 2022Article
- Adaptive Learning through Temporal Dynamics of State Representation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Computational models of adaptive behavior and prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Relative salience signaling within a thalamo-orbitofrontal circuit governs learning rate.Current biology : CB · 2021Article
- Article
- Timescales of Cognition in the Brain.Current opinion in behavioral sciences · 2021Article
- Modulation of Dopamine for Adaptive Learning: A Neurocomputational Model.Computational brain & behavior · 2021Article
- Integrating prediction errors at two time scales permits rapid recalibration of speech sound categories.eLife · 2020Article
- Adaptive learning under expected and unexpected uncertainty.Nature reviews. Neuroscience · 2019Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent experiments have shown that animals and humans have a remarkable ability to adapt their learning rate according to the volatility of the environment. Yet the neural mechanism responsible for such adaptive learning has remained unclear. To fill this gap, we investigated a biophysically inspired, metaplastic synaptic model within the context of a well-studied decision-making network, in which synapses can change their rate of plasticity in addition to their efficacy according to a reward-based learning rule. We found that our model, which assumes that synaptic plasticity is guided by a novel surprise detection system, captures a wide range of key experimental findings and performs as well as a Bayes optimal model, with remarkably little parameter tuning. Our results further demonstrate the computational power of synaptic plasticity, and provide insights into the circuit-level computation which underlies adaptive decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.