ReviewFertility and sterility2016
An old culprit but a new story: bisphenol A and "NextGen" bisphenols.
Review in Fertility and sterility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Biocompatible designated Resin-3D-printed polymers exhibit reproductive toxicity prevented by Parylene-C.bioRxiv : the preprint server for biology · 2026Article
- Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort.Environment international · 2025Article
- Prenatal exposure to environmental bisphenols over time and their association with childhood asthma, allergic rhinitis and atopic dermatitis in the ECHO consortium.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Bisphenol Exposure Disrupts Cytoskeletal Organization and Development of Pre-Implantation Embryos.Cells · 2022Article
- Article
- Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding.PloS one · 2021Article
- Identification of the Bisphenol A (BPA) and the Two Analogues BPS and BPF in Cryptorchidism.Frontiers in endocrinology · 2021Article
- Mechanisms underlying disruption of oocyte spindle stability by bisphenol compounds.Reproduction (Cambridge, England) · 2020Article
- Down syndrome.Nature reviews. Disease primers · 2020Review
- Bisphenol A Diglycidyl Ether (BADGE) and Bisphenol Analogs, but Not Bisphenol A (BPA), Activate the CatSper CaFrontiers in endocrinology · 2020Article
- Male exposure to bisphenol A (BPA) and semen quality in the Home Observation of Periconceptional Exposures (HOPE) cohort.Reproductive toxicology (Elmsford, N.Y.) · 2019Article
- Environmental toxins and the impact of other endocrine disrupting chemicals in women's reproductive health.JBRA assisted reproduction · 2019Review
- A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort.Environmental health : a global access science source · 2019Article
- Melatonin attenuates bisphenol A-induced toxicity of the adrenal gland of Wistar rats.Environmental science and pollution research international · 2019Article
- Replacement Bisphenols Adversely Affect Mouse Gametogenesis with Consequences for Subsequent Generations.Current biology : CB · 2018Article
- A Longitudinal Study of Estrogen-Responsive Tissues and Hormone Concentrations in Infants Fed Soy Formula.The Journal of clinical endocrinology and metabolism · 2018Article
- Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study.Environment international · 2018Article
- Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus?: An analysis using a high-sensitivity methylome technique.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2018Article
- Bisphenol-A exposure and gene expression in human luteinized membrana granulosa cells in vitro.Human reproduction (Oxford, England) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The concept that developmental events shape adult health and disease was sparked by the recognition of a link between maternal undernutrition and coronary disease in adults. From that beginning, a new field-the developmental origins of health and disease-emerged, and attention has focused on the effects of a wide array of developmental perturbations. Exposure to endocrine-disrupting chemicals has been of particular interest, and a ubiquitous environmental contaminant bisphenol A (BPA) has become the endocrine-disrupting chemical poster child. Bisphenol A has been the subject of intense investigation for nearly two decades, and exposure effects have been described in hundreds of experimental, epidemiological, and clinical studies. From the standpoint of reproductive health, the findings are particularly important, as they suggest that the ovary, testis, and reproductive tract in both sexes are targets of BPA action. The findings and the media and regulatory attention garnered by them have generated increasing public concern and resulted in legislative bans on BPA in some countries. The subsequent introduction of BPA-free products, although a masterful marketing strategy, is in reality only the beginning of a new and complex chapter of the BPA story. In this review we attempt to summarize what we have learned about the reproductive effects of BPA, present the reasons why studying the effects of this chemical in humans is no longer sufficient, and outline the challenges that the growing array of next generation bisphenols represents to clinicians, researchers, federal agencies, and the general public.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.