Evidence map›Paper›PMID 27504495›Full record

ArticleNeurology. Genetics2016

Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset.

Riley Bove, Alicia S Chua, Zongqi Xia, Lori Chibnik, Philip L De Jager, Tanuja Chitnis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Observational
  3. Review
  4. Review
  5. Review
  6. Review
  7. Gene-Environment Interactions in Multiple Sclerosis: A UK Biobank Study.Neurology(R) neuroimmunology & neuroinflammation · 2021
    Article
  8. Article
  9. Review
  10. Genetic risk factors for pediatric-onset multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2018
    Article
  11. Article
  12. Caring for Women with Multiple Sclerosis Across the Lifespan.Current neurology and neuroscience reports · 2018
    Review
  13. Review
  14. Multiple sclerosis journal - experimental, translational and clinical
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Riley BoveDepartment of Neurology (R.B., A.S.C., Z.X., P.L.D.J., T.C.), Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Brookline, MA; and Ann Romney Center for Neurologic Diseases (R.B., A.S.C., Z.X., L.C., P.L.D.J., T.C.), Harvard Medical School (R.B., Z.X., L.C., P.L.D.J., T.C.), Boston, MA.
Alicia S ChuaDepartment of Neurology (R.B., A.S.C., Z.X., P.L.D.J., T.C.), Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Brookline, MA; and Ann Romney Center for Neurologic Diseases (R.B., A.S.C., Z.X., L.C., P.L.D.J., T.C.), Harvard Medical School (R.B., Z.X., L.C., P.L.D.J., T.C.), Boston, MA.
Zongqi XiaDepartment of Neurology (R.B., A.S.C., Z.X., P.L.D.J., T.C.), Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Brookline, MA; and Ann Romney Center for Neurologic Diseases (R.B., A.S.C., Z.X., L.C., P.L.D.J., T.C.), Harvard Medical School (R.B., Z.X., L.C., P.L.D.J., T.C.), Boston, MA.
Lori ChibnikDepartment of Neurology (R.B., A.S.C., Z.X., P.L.D.J., T.C.), Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Brookline, MA; and Ann Romney Center for Neurologic Diseases (R.B., A.S.C., Z.X., L.C., P.L.D.J., T.C.), Harvard Medical School (R.B., Z.X., L.C., P.L.D.J., T.C.), Boston, MA.
Philip L De JagerDepartment of Neurology (R.B., A.S.C., Z.X., P.L.D.J., T.C.), Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Brookline, MA; and Ann Romney Center for Neurologic Diseases (R.B., A.S.C., Z.X., L.C., P.L.D.J., T.C.), Harvard Medical School (R.B., Z.X., L.C., P.L.D.J., T.C.), Boston, MA.
Tanuja ChitnisDepartment of Neurology (R.B., A.S.C., Z.X., P.L.D.J., T.C.), Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Brookline, MA; and Ann Romney Center for Neurologic Diseases (R.B., A.S.C., Z.X., L.C., P.L.D.J., T.C.), Harvard Medical School (R.B., Z.X., L.C., P.L.D.J., T.C.), Boston, MA.

Funding

Hormones/Genes in Women's Health: From Bench to BedsideK12HD051959 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, JILL M, REXRODE, KATHRYN M · 2005 to 2023
$8.8M
Leveraging genetics and environment to predict presymptomatic multiple sclerosisK08NS079493 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIA, ZONGQI · 2012 to 2016
$957k
Integrative analysis of genomic and epigenomic architecture in cognitive declineK25AG041906 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI CHIBNIK, LORI BETH · 2012 to 2016
$771k
NIA NIH HHS K25 AG041906NICHD NIH HHS K12 HD051959NINDS NIH HHS K08 NS079493
6 · The paper itself

Abstract

objectiveTo examine the relationship between 2 markers of early multiple sclerosis (MS) onset, 1 genetic (HLA-DRB1*1501) and 1 experiential (early menarche), in 2 cohorts.

methodsWe included 540 white women with MS or clinically isolated syndrome (N = 156 with genetic data available) and 1,390 white women without MS but with a first-degree relative with MS (Genes and Environment in Multiple Sclerosis [GEMS]). Age at menarche, HLA-DRB1*1501 status, and age at MS onset were analyzed.

resultsIn both cohorts, participants with at least 1 HLA-DRB1*1501 allele had a later age at menarche than did participants with no risk alleles (MS: mean difference = 0.49, 95% confidence interval [CI] = [0.03-0.95], p = 0.036; GEMS: mean difference = 0.159, 95% CI = [0.012-0.305], p = 0.034). This association remained after we adjusted for body mass index at age 18 (available in GEMS) and for other MS risk alleles, as well as a single nucleotide polymorphism near the HLA-A region previously associated with age of menarche (available in MS cohort). Confirming previously reported associations, in our MS cohort, every year decrease in age at menarche was associated with a 0.65-year earlier MS onset (95% CI = [0.07-1.22], p = 0.027, N = 540). Earlier MS onset was also found in individuals with at least 1 HLA-DRB1*1501 risk allele (mean difference = -3.40 years, 95% CI = [-6.42 to -0.37], p = 0.028, N = 156).

conclusionsIn 2 cohorts, a genetic marker for earlier MS onset (HLA-DRB1*1501) was inversely related to earlier menarche, an experiential marker for earlier symptom onset. This finding warrants broader investigations into the association between the HLA region and hormonal regulation in determining the onset of autoimmune disease.

Identifiers

PMID27504495
PMCPMC4962522

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.