Evidence map›Paper›PMID 27504486›Full record

ReviewSurgery research and practice2016

Future Perspectives of ERAS: A Narrative Review on the New Applications of an Established Approach.

Dario Bugada, Valentina Bellini, Andrea Fanelli, Maurizio Marchesini, Christian Compagnone, Marco Baciarello, Massimo Allegri, Guido Fanelli

Registry-linked trialAbstract readReview
In one paragraph

Review in Surgery research and practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03172988 (Impact of Perioperative Dexamethasone and Flurbiprofen Axetil on Long-term Survival After Surgery for Non-small Cell Lung Cancer), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03172988 phase4terminatednot on this mapstarted 2017, after this paper: background citation

Impact of Perioperative Dexamethasone and Flurbiprofen Axetil on Long-term Survival After Surgery for Non-small Cell Lung Cancer: A 2x2 Factorial Randomized Controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2017 to 2018Enrolled126ConditionsCarcinoma, Non-Small-Cell Lung, Surgery, Dexamethasone, Flubiprofen AxetilArmsDexamethasone, Normal saline, Flurbiprofen axetil, Lipid microsphere
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dario Bugada2 Anestesia Anestesia, Rianimazione e Terapia del Dolore, Azienda Ospedaliero Universitaria, Via Gramsci 14, 43126 Parma, Italy; Department of Surgical Sciences, University of Parma, Via Gramsci 14, 43126 Parma, Italy; SIMPAR Group (Study in Multidisciplinary Pain Research), Italy.ORCID 0000-0002-8363-6674
Valentina Bellini2 Anestesia Anestesia, Rianimazione e Terapia del Dolore, Azienda Ospedaliero Universitaria, Via Gramsci 14, 43126 Parma, Italy.ORCID 0000-0001-7993-9026
Andrea FanelliU.O. Anestesia e Terapia Intensiva Polivalente, Azienda Ospedaliero-Universitaria Policlinico S. Orsola-Malpighi, Via Albertoni 15, 40138 Bologna, Italy.ORCID 0000-0001-9325-877X
Maurizio Marchesini2 Anestesia Anestesia, Rianimazione e Terapia del Dolore, Azienda Ospedaliero Universitaria, Via Gramsci 14, 43126 Parma, Italy; SIMPAR Group (Study in Multidisciplinary Pain Research), Italy.
Christian Compagnone2 Anestesia Anestesia, Rianimazione e Terapia del Dolore, Azienda Ospedaliero Universitaria, Via Gramsci 14, 43126 Parma, Italy; Department of Surgical Sciences, University of Parma, Via Gramsci 14, 43126 Parma, Italy.ORCID 0000-0001-9951-5503
Marco Baciarello2 Anestesia Anestesia, Rianimazione e Terapia del Dolore, Azienda Ospedaliero Universitaria, Via Gramsci 14, 43126 Parma, Italy; Department of Surgical Sciences, University of Parma, Via Gramsci 14, 43126 Parma, Italy.ORCID 0000-0002-6939-9764
Massimo Allegri2 Anestesia Anestesia, Rianimazione e Terapia del Dolore, Azienda Ospedaliero Universitaria, Via Gramsci 14, 43126 Parma, Italy; Department of Surgical Sciences, University of Parma, Via Gramsci 14, 43126 Parma, Italy; SIMPAR Group (Study in Multidisciplinary Pain Research), Italy.
Guido Fanelli2 Anestesia Anestesia, Rianimazione e Terapia del Dolore, Azienda Ospedaliero Universitaria, Via Gramsci 14, 43126 Parma, Italy; Department of Surgical Sciences, University of Parma, Via Gramsci 14, 43126 Parma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ERAS approach (Enhanced Recovery After Surgery) is a multimodal, perioperative pathway designed to achieve early recovery after surgery. ERAS has shown documented efficacy in elective surgery, and the concept of "multimodal" and "multidisciplinary" approach seems still to be of higher importance than each single item within ERAS protocols. New perspectives include the use of ERAS in emergency surgery, where efficacy and safety on outcome have been documented, and flexibility of traditional items may add benefits for traditionally high-risk patients. Obstetric surgery, as well, may open wide horizons for future research, since extremely poor data are currently available, and ERAS benefits may translate even on the baby. Finally, the concept of "outcome" may be extended when considering the specific setting of cancer surgery, in which variables like cancer recurrence, early access to adjuvant therapies, and, finally, long-term survival are as important as the reduced perioperative complications. In this perspective, different items within ERAS protocols should be reinterpreted and eventually integrated towards "protective" techniques, to develop cancer-specific ERAS approaches keeping pace with the specific aims of oncologic surgery.

Identifiers

PMID27504486
PMCPMC4967675

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.