ArticleJournal of clinical and diagnostic research : JCDR2016
Estimation of Salivary and Serum Biomarkers in Diabetic and Non Diabetic Patients - A Comparative Study.
Article in Journal of clinical and diagnostic research : JCDR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Potential of Saliva in Stroke Patients: A Review.International journal of molecular sciences · 2026Review
- Exploring Saliva as a Sample for Non-Invasive Glycemic Monitoring in Diabetes: A Scoping Review.Biomedicines · 2025Review
- The intensity of free radical processes and chaperone activity in the saliva of patients with type 2 diabetes.BioMedicine · 2023Article
- Effectiveness of Salivary Glucose as a Reliable Alternative in Diagnosis of Type 1 Diabetes Mellitus: A Cross-Sectional Study.Journal of pharmacy & bioallied sciences · 2022Article
- Advanced wearable biosensors for the detection of body fluids and exhaled breath by graphene.Mikrochimica acta · 2022Review
- Salivary Neurotrophins Brain-Derived Neurotrophic Factor and Nerve Growth Factor Associated with Childhood Obesity: A Multiplex Magnetic Luminescence Analysis.Diagnostics (Basel, Switzerland) · 2022Article
- Salivary phosphate as a biomarker for human diseases.FASEB bioAdvances · 2022Article
- Evaluation of Salivary Components and Dental Plaque in Relation to Dental Caries Status in Type 1 Diabetes Mellitus.International journal of clinical pediatric dentistry · 2022Article
- Salivary gland proteins alterations in the diabetic milieu.Journal of molecular histology · 2021Review
- Salivary exosomes as a new therapy to ameliorate diabetes mellitus and combat xerostomia and submandibular salivary glands dysfunction in diabetic rats.Journal of molecular histology · 2021Article
- Changes in Salivary Amylase and Glucose in Diabetes: A Scoping Review.Diagnostics (Basel, Switzerland) · 2021Article
- Article
- Saliva diagnostic utility in patients with type 2 diabetes: Future standard method.Journal of medical biochemistry · 2020Article
- Sialometric and Sialochemical Analysis in Individuals With Pulp Stones.Frontiers in cell and developmental biology · 2020Article
- Salivary creatinine as a diagnostic tool for evaluating patients with chronic kidney disease.BMC nephrology · 2019Article
- Article
- Salivary glucose as a non-invasive biomarker of type 2 diabetes mellitus.Journal of clinical and experimental dentistry · 2018Article
- Article
- Advancing Point-of-Care (PoC) Testing Using Human Saliva as Liquid Biopsy.Diagnostics (Basel, Switzerland) · 2017Review
- A stretchable and screen-printed electrochemical sensor for glucose determination in human perspiration.Biosensors & bioelectronics · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBlood is the gold standard body fluid for diagnosis of Diabetes Mellitus (DM) but saliva offers an alternative to serum as a biological fluid for diagnostic purposes because it contains serum constituents.
aimThe study was conducted to estimate and compare serum and salivary glucose, amylase, proteins, calcium and phosphorus levels in DM and healthy subjects and to evaluate whether saliva can be used as a diagnostic fluid in DM patients. MATERIALS AND
methodsStudy consisted of 120 subjects from OPD of Surendera Dental College, Sriganganagar, Rajasthan, India. The study groups were divided into Group I-60 DM patients (Type I & II) and Group II-60 healthy subjects. The saliva and serum samples were collected from each subject and levels of different biochemical parameters were estimated.
resultsMean serum level of glucose (211.50 ± 43.82), amylase (79.86 ± 16.23), total proteins (6.65 ± 0.84), calcium (7.17 ± 0.91) and phosphorus (3.68±0.65) as observed in Group I while in Group II, glucose (88.81±11.29), amylase (77.67±14.88), total proteins (6.35±0.76), calcium (7.52±0.97) and phosphorus (3.96 ± 0.91) were noted. Mean salivary level of glucose (14.10±6.99), amylase (1671.42±569.86), total proteins (1.33±1.11), calcium (10.06±2.76) and phosphorus (13.75±4.45) as observed in Group I while in Group II, glucose (5.87± 2.42), amylase (1397.59 ±415.97), total proteins (1.36±0.81), calcium (7.73±2.78) and phosphorus (8.39 ± 1.95) were noted. On comparing values in saliva and serum, among two groups, an insignificant difference (p>0.005) was found between few of them.
conclusionValues regarding blood and salivary biochemical parameters were distinctly different between two groups suggesting salivary parameters can be used as a diagnostic alternative to blood parameters for diabetes mellitus.
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