ArticleJournal of clinical and diagnostic research : JCDR2016
Expression of CD1a by Langerhan's Cells in Oral Lichen Planus - A Retrospective Analysis.
Article in Journal of clinical and diagnostic research : JCDR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- MAIT cells modulating the oral lichen planus immune microenvironment: a cellular crosstalk perspective.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system.Experimental & molecular medicine · 2023Review
- Langerhans Cells, T Cells, and B Cells in Oral Lichen Planus and Oral Leukoplakia.International journal of dentistry · 2022Article
- Oral lichen planus: a microbiologist point of view.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Review
- Marking vertebrates langerhans cells, from fish to mammals.Acta histochemica · 2020Review
- Pilot GWAS of caries in African-Americans shows genetic heterogeneity.BMC oral health · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLangerhan's Cells (LCs) are dendritic cells of the oral epithelium which play a role in a series of oral lesions from gingivitis to oral cancer. Oral Lichen Planus (OLP) is an oral mucosal T-lymphocyte mediated immunologic reaction to an unidentified putative antigen or allergen.
aimThe aim of this study was to quantify the presence of immature LCs in OLP comparing them with normal epithelium. MATERIALS AND
methodsA retrospective study using 30 of OLP cases were conducted. Immunohistochemistry was performed using polyclonal anti-CD1a antibodies to identify LCs in 10 cases of normal tissue and 30 samples of OLP. The distribution of LCs among lesional tissue and normal mucosa was analysed using Mann-Whitney U test.
resultsLC population in OLP was significantly higher when compared to the normal epithelium (p<0.001).
conclusionThe increase in LCs indicates the active role played during the antigen detection in OLP and subsequent presentation to T-lymphocytes.
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Registered trials
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