ReviewJournal of clinical and diagnostic research : JCDR2016
Clinical and Neuroradiological Spectrum of Metronidazole Induced Encephalopathy: Our Experience and the Review of Literature.
Review in Journal of clinical and diagnostic research : JCDR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Metronidazole-induced encephalopathy: a systematic review.Journal of neurology · 2020Pooled it
- Reversible Metronidazole-Induced Encephalopathy With Typical MRI Features Following a Low Cumulative Dose: Case Report.Clinical medicine insights. Case reports · 2026Article
- Anti-Pharmaceuticals (Basel, Switzerland) · 2025Article
- Metronidazole-induced cerebellar dysfunction: An underdiagnosed identity.Journal of family medicine and primary care · 2025Article
- Rare case of metronidazole-induced encephalopathy in a multiple transplant recipient: Clinical and radiological insights.Clinical case reports · 2025Article
- Case Report: Metronidazole-induced encephalopathy in a patient with acute myeloid leukemia type 2 and a literature review of the pediatric case reports.Frontiers in pediatrics · 2025Article
- Metronidazole-induced Encephalopathy.Internal medicine (Tokyo, Japan) · 2024Article
- Article
- An Unusual Case of Metronidazole-induced Encephalopathy in a Patient with Hereditary Hemorrhagic Telangiectasia.Journal of community hospital internal medicine perspectives · 2024Article
- Paraneoplastic Neurological Syndromes of the Central Nervous System: Pathophysiology, Diagnosis, and Treatment.Biomedicines · 2023Review
- Diffuse subcortical white matter restriction: An uncommon finding on metronidazole toxicity.The neuroradiology journal · 2023Article
- Article
- Metronidazole-Induced Encephalopathy in a 16-Year-Old Girl with Crohn's Disease: Case Report and Review of the Pediatric Literature.Children (Basel, Switzerland) · 2022Article
- MRI Findings and Topographic Distribution of Lesions in Metronidazole-Induced Encephalopathy.Cureus · 2022Article
- Kinetic and Molecular Docking Studies to Determine the Effect of Inhibitors on the Activity and Structure of Fused G6PD::6PGL Protein fromMolecules (Basel, Switzerland) · 2022Article
- Stressor-Induced Reduction in Cognitive Behavior is Associated with Impaired Colonic Mucus Layer Integrity and is Dependent Upon the LPS-Binding Protein Receptor CD14.Journal of inflammation research · 2022Article
- Antibiotics and the Nervous System-Which Face of Antibiotic Therapy Is Real, Dr. Jekyll (Neurotoxicity) or Mr. Hyde (Neuroprotection)?Molecules (Basel, Switzerland) · 2021Review
- Metronidazole Induced Cerebellar Toxicity: A Case Report.JNMA; journal of the Nepal Medical Association · 2021Article
- A case report of toxic leukoencephalopathy induced by metronidazole in a woman with surgical site infection.Clinical case reports · 2021Article
- Metronidazole-associated Neurologic Events: A Nested Case-control Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metronidazole is an antimicrobial agent mainly used in the treatment of several protozoal and anaerobic infections, additionally, is often used in hepatic encephalopathy and Crohn disease. Apart from peripheral neuropathy, metronidazole can also cause symptoms of central nervous system dysfunction like ataxic gait, dysarthria, seizures, and encephalopathy which may result from both short term and chronic use of this drug and is collectively termed as "metronidazole induced encephalopathy"(MIE). Neuroimaging forms the backbone in clinching the diagnosis of this uncommon entity, especially in cases where there is high index of suspicion of intoxication. Although typical sites of involvement include cerebellum, brain stem and corpus callosum, however, lesions of other sites have also been reported. Once diagnosed, resolution of findings on Magnetic Resonance Imaging (MRI) of the Brain along with clinical improvement remains the mainstay of monitoring. Here we review the key clinical features and MRI findings of MIE as reported in medical literature. We also analyze implication of use of this drug in special situations like hepatic encephalopathy and brain abscess and discuss our experience regarding this entity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.