Evidence map›Paper›PMID 27504268›Full record

ArticleJournal of developmental biology2016

Hedgehog Signalling in the Embryonic Mouse Thymus.

Alessandro Barbarulo, Ching-In Lau, Konstantinos Mengrelis, Susan Ross, Anisha Solanki, José Ignacio Saldaña, Tessa Crompton

Abstract read
In one paragraph

Article in Journal of developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alessandro Barbarulo *Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.
Ching-In Lau *Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.
Konstantinos Mengrelis *Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.
Susan Ross *Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.
Anisha Solanki *Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.
José Ignacio SaldañaImmunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.
Tessa CromptonImmunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.

Funding

Medical Research Council G0900161Wellcome Trust 094255
6 · The paper itself

Abstract

T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte-TEC cross-talk in the embryonic mouse thymus during the last week of gestation.

Indexed as

Gli1Gli2Gli3HedgehogIhhShhT cell developmentthymic epithelial cell (TEC)thymus

Identifiers

PMID27504268
PMCPMC4975939

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.