Evidence map›Paper›PMID 27504259›Full record

ArticleResults in immunology2016

Constitutive expression of genes encoding notch receptors and ligands in developing lymphocytes, nTreg cells and dendritic cells in the human thymus.

Luciana Bento-de-Souza, Jefferson R Victor, Luiz C Bento-de-Souza, Magaly Arrais-Santos, Andréia C Rangel-Santos, Érica Pereira-Costa, Elaine Raniero-Fernandes, Maria I Seixas-Duarte, João B Oliveira-Filho, Alberto J Silva Duarte

Open access · hybridAbstract read
In one paragraph

Article in Results in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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  10. Preconception allergen sensitization can induce B10 cells in offspring: a potential main role for maternal IgG.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Luciana Bento-de-SouzaLaboratory of Medical Investigation in Dermatology and Immunodeficiencies (LIM56), School of Medicine - USP, São Paulo, Brazil; Laboratory of Pathology of Transmissible Diseases, School of Medicine - USP, São Paulo, Brazil.
Jefferson R VictorLaboratory of Medical Investigation in Dermatology and Immunodeficiencies (LIM56), School of Medicine - USP, São Paulo, Brazil.
Luiz C Bento-de-SouzaHeart Hospital - Hcor, São Paulo, Brazil.
Magaly Arrais-SantosHeart Hospital - Hcor, São Paulo, Brazil.
Andréia C Rangel-SantosLaboratory of Medical Investigation in Dermatology and Immunodeficiencies (LIM56), School of Medicine - USP, São Paulo, Brazil.
Érica Pereira-CostaLaboratory of Medical Investigation in Dermatology and Immunodeficiencies (LIM56), School of Medicine - USP, São Paulo, Brazil.
Elaine Raniero-FernandesInstitute of Integrative Medicine Professor Fernando Figueira - IMIP, Recife, PE, Brazil.
Maria I Seixas-DuarteLaboratory of Pathology of Transmissible Diseases, School of Medicine - USP, São Paulo, Brazil.
João B Oliveira-FilhoInstitute of Integrative Medicine Professor Fernando Figueira - IMIP, Recife, PE, Brazil.
Alberto J Silva DuarteLaboratory of Medical Investigation in Dermatology and Immunodeficiencies (LIM56), School of Medicine - USP, São Paulo, Brazil; Heart Hospital - Hcor, São Paulo, Brazil.
Instituto de Medicina Integral Professor Fernando Figueira · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs), suggesting their participation in human thymocyte maturation. nTreg analyses indicated that the Notch components function in parallel to promote maturation in the thymus.

Indexed as

NotchTDCSThymusTreg

Identifiers

PMID27504259
PMCPMC4969261
OpenAlexW2312926907

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.