ArticleNeural plasticity2016
Altered Cerebellar Circuitry following Thoracic Spinal Cord Injury in Adult Rats.
Article in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Changes in Cerebral Glucose Metabolism at Rest Following Hemicontusive Cervical Spinal Cord Injury in Mice: A Whole-Brain Autoradiographic Study.The European journal of neuroscience · 2026Article
- Metabolic profile of complete spinal cord injury in pons and cerebellum: A 3T 1H MRS study.Scientific reports · 2023Article
- Cerebellum regulating cerebral functional cortex through multiple pathways in complete thoracolumbar spinal cord injury.Frontiers in neuroscience · 2022Article
- Cerebellar contribution to sensorimotor adaptation deficits in humans with spinal cord injury.Scientific reports · 2021Article
- Targeting Sensory and Motor Integration for Recovery of Movement After CNS Injury.Frontiers in neuroscience · 2021Review
- Quantitative MRI of rostral spinal cord and brain regions is predictive of functional recovery in acute spinal cord injury.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Cerebellar function is critical for coordinating movement and motor learning. However, events occurring in the cerebellum following spinal cord injury (SCI) have not been investigated in detail. We provide evidence of SCI-induced cerebellar synaptic changes involving a loss of granule cell parallel fiber input to distal regions of the Purkinje cell dendritic tree. This is accompanied by an apparent increase in synaptic contacts to Purkinje cell proximal dendrites, presumably from climbing fibers originating in the inferior olive. We also observed an early stage injury-induced decrease in the levels of cerebellin-1, a synaptic organizing molecule that is critical for establishing and maintaining parallel fiber-Purkinje cell synaptic integrity. Interestingly, this transsynaptic reorganizational pattern is consistent with that reported during development and in certain transgenic mouse models. To our knowledge, such a reorganizational event has not been described in response to SCI in adult rats. Regardless, the novel results of this study are important for understanding SCI-induced synaptic changes in the cerebellum, which may prove critical for strategies focusing on promoting functional recovery.
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