ArticleJournal of neurodevelopmental disorders2016
Neurophysiological hyperresponsivity to sensory input in autism spectrum disorders.
Article in Journal of neurodevelopmental disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Visual Responsivity in Autism: Measuring Visual Responses in Autistic and Non-Autistic Adults Using Psychophysics, fMRI, and EEG.Autism research : official journal of the International Society for Autism Research · 2026Article
- The Influence of Sensory Processing on Executive Function in Young Autistic Children.Journal of autism and developmental disorders · 2026Article
- Article
- Impaired thalamic burst firing in fragile X syndrome.Cell reports · 2025Article
- Sex differences during development in cortical temporal processing and event related potentials in wild-type and fragile X syndrome model mice.Journal of neurodevelopmental disorders · 2024Article
- Developmental delays in cortical auditory temporal processing in a mouse model of Fragile X syndrome.Journal of neurodevelopmental disorders · 2023Article
- Prenatal marijuana exposure and visual perception in toddlers: Evidence of a sensory processing deficit.Frontiers in pediatrics · 2023Article
- Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- A family study of symbolic learning and synaptic plasticity in autism spectrum disorder.Frontiers in human neuroscience · 2022Article
- A case-control study of visual, auditory and audio-visual sensory interactions in children with autism spectrum disorder.Journal of vision · 2021Article
- Immunoceptive inference: why are psychiatric disorders and immune responses intertwined?Biology & philosophy · 2021Article
- Hyperacusis in Children with Attention Deficit Hyperactivity Disorder: A Preliminary Study.International journal of environmental research and public health · 2020Article
- Late fMRI Response Components Are Altered in Autism Spectrum Disorder.Frontiers in human neuroscience · 2020Article
- Assessments of Amino Acids, Ammonia and Oxidative Stress Among Cohort of Egyptian Autistic Children: Correlations with Electroencephalogram and Disease Severity.Neuropsychiatric disease and treatment · 2020Article
- Lesser suppression of response to bright visual stimuli and visual abnormality in children with autism spectrum disorder: a magnetoencephalographic study.Journal of neurodevelopmental disorders · 2019Article
- Review
- Conceptual, Regulatory and Strategic Imperatives in the Early Days of EEG-Based Biomarker Validation for Neurodevelopmental Disabilities.Frontiers in integrative neuroscience · 2019Review
- A Study of the Correlation between VEP and Clinical Severity in Children with Autism Spectrum Disorder.Autism research and treatment · 2018Article
- Neural Hyperexcitability in Autism Spectrum Disorders.Brain sciences · 2017Review
- Multisensory integration in C. elegans.Current opinion in neurobiology · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAtypical sensory processing is a common clinical observation in autism spectrum disorder (ASD). Neural hyperexcitability has been suggested as the cause for sensory hypersensitivity, a frequently reported clinical observation in ASD. We examined visual evoked responses to parametric increases in stimulus contrast in order to model neural responsivity of sensory systems in ASD.
methodsThirteen high-functioning individuals with ASD and 12 typically developing (TD) individuals completed a steady-state visual evoked potential study. Stimuli were vertical circular gratings oscillating at 3.76 Hz at varying contrasts (5, 10, 20,…, 90 % contrast, 10 levels). The average spectral power at the stimulus oscillation frequency was calculated for each contrast level.
resultsThe magnitude of evoked sensory responses increased at a significantly greater rate and resulted in disproportionately elevated activation with higher contrasts in the ASD group. Approximately 45 % of ASD participants had rates of response increases greater than any TD participant. This alteration was highly associated with parental reports of these participants' sensory difficulties.
conclusionsGreater increases in visual responses over contrast manipulation suggest heightened excitability in the sensory cortex in ASD participants. Heightened neural excitability was observed in a substantial portion but not all of the ASD participants. This pattern suggests that individuals with higher excitability may constitute a neurobiologically distinct subgroup requiring individualized treatment interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.