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The Stepwise Approach to Diabetes Prevention: Results From the D-CLIP Randomized Controlled Trial.
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What was examined
lifestyle curriculum plus stepwise addition of metformin
standard lifestyle advice
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- Paper abstract ↗ · Abstractabstract · Matched to source text; not expert scientific review
RESULTS: During 3 years of follow-up, 34.9% of control and 25.7% of intervention participants developed diabetes (P = 0.014); the relative risk reduction (RRR) was 32% (95% CI 7-50), and the number needed to treat to prevent one case of diabetes was 9.8.
- Paper abstract ↗ · Abstractabstract · Matched to source text; not expert scientific review
Diabetes Prevention Program-based lifestyle curriculum plus stepwise addition of metformin (500 mg, twice daily) for participants at highest risk of conversion to diabetes at ≥4 months of follow-up.
- Paper abstract ↗ · Abstractabstract · Matched to source text; not expert scientific review
Eligible individuals were identified through community-based recruitment and randomized to standard lifestyle advice (control) or a 6-month, culturally tailored, U.S.