Evidence map›Paper›PMID 27503998›Full record

ReviewCold Spring Harbor perspectives in medicine2016

Mechanisms of Nucleosome Dynamics In Vivo.

Steven Henikoff

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Multiple Roles of dXNP and dADD1-International journal of molecular sciences · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Histone Tail Conformations: A Fuzzy Affair with DNA.Trends in biochemical sciences · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  14. Review
  15. Regulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System.Advances in experimental medicine and biology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Steven HenikoffHoward Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.

Funding

Epigenomic profiling of histone turnover kinetics in mammalian cellsR01ES020116 · NIEHS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HENIKOFF, STEVEN · 2010 to 2014
$2.4M
NIEHS NIH HHS R01 ES020116
6 · The paper itself

Abstract

Nucleosomes function to tightly package DNA into chromosomes, but the nucleosomal landscape becomes disrupted during active processes such as replication, transcription, and repair. The realization that many proteins responsible for chromatin regulation are frequently mutated in cancer has drawn attention to chromatin dynamics; however, the basic mechanisms whereby nucleosomes are disrupted and reassembled is incompletely understood. Here, I present an overview of chromatin dynamics as has been elucidated in model organisms, in which our understanding is most advanced. A basic understanding of chromatin dynamics during normal developmental processes can provide the context for understanding how this machinery can go awry during oncogenesis.

Indexed as

ChromatinChromatin Assembly and DisassemblyDNADNA ReplicationHistonesNucleosomesChromatinDNAHistonesNucleosomes

Identifiers

PMID27503998
PMCPMC5008063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.