ArticleProceedings of the National Academy of Sciences of the United States of America2016
Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Article
- The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories.Journal of anatomy · 2026Article
- The MacBrain Resource Center (MBRC) rhesus macaque embryonic brain histology datasets.Journal of anatomy · 2026Article
- Typical development of the human fetal subplate: Regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Accomplishments of "Old-Fashioned" Electron Microscopy in the Period of Dominance of Immunofluorescent Methods.International journal of molecular sciences · 2026Review
- Orchestrated molecular changes of proliferative, migratory-fibrillar, synaptic, and postmigratory compartments align with precocious cortex-type specification in the early human pallium.Journal of anatomy · 2026Article
- Transcriptomic divergence of network hubs in the prenatal human brain.Communications biology · 2025Article
- Typical development of the human fetal subplate: regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.bioRxiv : the preprint server for biology · 2025Article
- Ex vivo Magnetic Resonance Imaging of the Human Fetal Brain.Developmental neuroscience · 2025Review
- Initial regional cytoarchitectonic differences in dorsal and orbitobasal human developing frontal cortex revealed by spatial transcriptomics.Brain structure & function · 2024Article
- Molecular Lineages and Spatial Distributions of Subplate Neurons in the Human Fetal Cerebral Cortex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Development of the basic architecture of neocortical circuitry in the human fetus as revealed by the coupling spatiotemporal pattern of synaptogenesis along with microstructure and macroscale in vivo MR imaging.Brain structure & function · 2024Article
- Lateral expansion of the mammalian cerebral cortex is related to anchorage of centrosomes in apical neural progenitors.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Correlation between the number of interstitial neurons of the white matter and number of neurons within cortical layers: Histological analyses in postnatal macaque.The Journal of comparative neurology · 2024Article
- 5-Bromo-2'-deoxyuridine labeling: historical perspectives, factors influencing the detection, toxicity, and its implications in the neurogenesis.Neural regeneration research · 2024Review
- Imaging of the superficial white matter in health and disease.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Neurogenesis in primates versus rodents and the value of non-human primate models.National science review · 2023Review
- Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex.Nature communications · 2023Article
- Geodesic theory of long association fibers arrangement in the human fetal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Associations between mother's depressive symptoms during pregnancy and newborn's brain functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
2 more citing papers are in PubMed but not listed here.
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Abstract
The subplate (SP) was the last cellular compartment added to the Boulder Committee's list of transient embryonic zones [Bystron I, Blakemore C, Rakic P (2008) Nature Rev Neurosci 9(2):110-122]. It is highly developed in human and nonhuman primates, but its origin, mode, and dynamics of development, resolution, and eventual extinction are not well understood because human postmortem tissue offers only static descriptive data, and mice cannot serve as an adequate experimental model for the distinct regional differences in primates. Here, we take advantage of the large and slowly developing SP in macaque monkey to examine the origin, settling pattern, and subsequent dispersion of the SP neurons in primates. Monkey embryos exposed to the radioactive DNA replication marker tritiated thymidine ([(3)H]dT, or TdR) at early embryonic ages were killed at different intervals postinjection to follow postmitotic cells' positional changes. As expected in primates, most SP neurons generated in the ventricular zone initially migrate radially, together with prospective layer 6 neurons. Surprisingly, mostly during midgestation, SP cells become secondarily displaced and widespread into the expanding SP zone, which becomes particularly wide subjacent to the association cortical areas and underneath the summit of its folia. We found that invasion of monoamine, basal forebrain, thalamocortical, and corticocortical axons is mainly responsible for this region-dependent passive dispersion of the SP cells. Histologic and immunohistochemical comparison with the human SP at corresponding fetal ages indicates that the same developmental events occur in both primate species.
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