ArticleHuman brain mapping2016
Early changes of brain connectivity in primary open angle glaucoma.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Methods of diffusion MRI tractography for localization of the anterior optic pathway: A systematic review of validated methods.NeuroImage. Clinical · 2023Pooled it
- Dual Mechanisms of Impaired Visual Processing in Glaucoma: Insights From Resting-State and Task-Related EEG.Investigative ophthalmology & visual science · 2026Article
- Cognitive impairment in glaucoma.Indian journal of ophthalmology · 2026Review
- Neurophysiological Evidence of Visual Cortical Alterations in Mild Primary Glaucoma: A Resting-State EEG Microstate Study.Brain topography · 2026Article
- The Connectivity of the Resting Brain in Primary Open-Angle Glaucoma: A Systematic Review.Biomedicines · 2025Review
- Glaucoma and brain functional networks: a bidirectional Mendelian randomisation study.BMJ open ophthalmology · 2025Article
- Cerebellar dysfunction in glaucoma patients.Brain communications · 2025Article
- Influence of intraocular and blood pressure on brain volumes: Observational and Mendelian randomization analyses.iScience · 2024Article
- Gaze behavior in open-angle glaucoma patients during visuo-cognitive-motor tasks: a cross-sectional study.Scientific reports · 2024Article
- Convolutional neural network-based classification of glaucoma using optic radiation tissue properties.Communications medicine · 2024Article
- Normal-Tension Glaucoma and Potential Clinical Links to Alzheimer's Disease.Journal of clinical medicine · 2024Review
- Elevated Intraocular Pressure Moderated Brain Morphometry in High-tension Glaucoma: a Structural MRI Study.Clinical neuroradiology · 2024Article
- Altered stability of dynamic brain functional architecture in primary open-angle glaucoma: a surface-based resting-state fMRI study.Brain imaging and behavior · 2024Article
- Diffusion tensor imaging of optic neuropathies: a narrative review.Quantitative imaging in medicine and surgery · 2024Review
- Abnormal Topological Organization of White Matter Structural Networks in Normal Tension Glaucoma Revealed via Diffusion Tensor Tractography.Brain sciences · 2023Article
- Impact of glaucoma on the spatial frequency processing of scenes in central vision.Visual neuroscience · 2023Article
- Effects of primary angle-closure glaucoma on interhemispheric functional connectivity.Frontiers in neuroscience · 2023Article
- Reduced brain subcortical volumes in patients with glaucoma: a pilot neuroimaging study using the region-of-interest-based approach.BMC neurology · 2022Article
- Microstructural Visual Pathway White Matter Alterations in Primary Open-Angle Glaucoma: A Neurite Orientation Dispersion and Density Imaging Study.AJNR. American journal of neuroradiology · 2022Article
- Visual Tract Degradation in Bilateral Normal-Tension Glaucoma-Cortical Thickness Maps and Volumetric Study of Visual Pathway Areas.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our aim was to assess in primary open angle glaucoma (POAG), a major cause of irreversible blindness worldwide, whether diffuse brain changes recently shown in advanced stage can be detected since the early stage. We used multimodal magnetic resonance imaging (MRI) in 57 patients with the three POAG stages and in 29 age-matched normal controls (NC). Voxelwise statistics was performed with nonparametric permutation testing. Compared with NC, disrupted anatomical connectivity (AC) was found in the whole POAG group along the visual pathway and in nonvisual white matter tracts (P < 0.001). Moreover, POAG patients showed decreased functional connectivity (FC) in the visual (P = 0.004) and working memory (P < 0.001) networks whereas an increase occurred in the default mode (P = 0.002) and subcortical (P < 0.001) networks. Altered AC and FC were already present in early POAG (n = 14) in both visual and nonvisual systems (P ≤ 0.01). Only severe POAG (n = 30) showed gray matter atrophy and this mapped on visual cortex (P < 0.001) and hippocampus (P < 0.001). Increasing POAG stage was associated with worsening AC in both visual and nonvisual pathway (P < 0.001), progressive atrophy in the hippocampus and frontal cortex (P < 0.003). Most of the structural and functional alterations within and outside the visual system showed correlation (P < 0.001 to 0.02) with computerized visual field and retinal nerve fiber layer thickness. In conclusion, the complex pathogenesis of POAG includes widespread damage of AC and altered FC within and beyond the visual system since the early disease stage. The association of brain MRI changes with measures of visual severity emphasizes the clinical relevance of our findings. Hum Brain Mapp 37:4581-4596, 2016. © 2016 Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.