Evidence map›Paper›PMID 27503655›Full record

ArticleAntimicrobial agents and chemotherapy2016

Determining the Optimal Carbapenem MIC That Distinguishes Carbapenemase-Producing and Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae.

Pranita D Tamma, Yanjie Huang, Belita N A Opene, Patricia J Simner

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. AMRrounds: Metallo-β-lactamase-producingJAC-antimicrobial resistance · 2025
    Article
  2. Article
  3. Emergence of pandrug-resistant carbapenemase-producingFrontiers in cellular and infection microbiology · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Carbapenem antibiotic stress increases blaJournal of clinical laboratory analysis · 2022
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Rapid Susceptibility Testing Methods.Clinics in laboratory medicine · 2019
    Review
  15. Review
  16. Case Report of an Extensively Drug-ResistantOpen forum infectious diseases · 2018
    Article
  17. Treatment outcome of non-carbapenemase-producing carbapenem-resistant Klebsiella pneumoniae infections: a multicenter study in Taiwan.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pranita D TammaDivision of Pediatric Infectious Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA ptamma1@jhmi.edu.
Yanjie HuangDepartment of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Belita N A OpeneDivision of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Patricia J SimnerDivision of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbapenemase-producing (CP) Enterobacteriaceae are largely responsible for the rapid spread of carbapenem-resistant Enterobacteriaceae (CRE). Distinguishing CP-CRE from non-CP-CRE has important infection control implications. In a cohort of 198 CRE isolates, for isolates that remained susceptible or intermediate to some carbapenem antibiotics, an ertapenem MIC of 0.5 μg/ml and meropenem, imipenem, and doripenem MICs of 2 μg/ml were best able to distinguish CP-CRE from non-CP-CRE isolates.

Indexed as

Bacterial Proteinsbeta-LactamasesCarbapenemsDrug Resistance, BacterialEnterobacteriaceaeHumansMicrobial Sensitivity TestsROC CurveBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenems

Identifiers

PMID27503655
PMCPMC5038245

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.