Evidence map›Paper›PMID 27503650›Full record

ArticleAntimicrobial agents and chemotherapy2016

First Report of the Globally Disseminated IncX4 Plasmid Carrying the mcr-1 Gene in a Colistin-Resistant Escherichia coli Sequence Type 101 Isolate from a Human Infection in Brazil.

Miriam R Fernandes, John A McCulloch, Marco A Vianello, Quézia Moura, Paula J Pérez-Chaparro, Fernanda Esposito, Luciana Sartori, Milena Dropa, Maria H Matté, Débora P A Lira and 2 more

Abstract readCase Reports
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Case Report: Transferable IncX4 plasmid carryingFrontiers in veterinary science · 2025
    Article
  5. Photoinactivation of Multidrug-ResistantACS applied bio materials · 2024
    Article
  6. Detection ofPathogens (Basel, Switzerland) · 2024
    Article
  7. Article
  8. Article
  9. Gram-negative bacilli carrying mcr gene in Brazil: a pathogen on the rise.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Review
  10. Article
  11. Article
  12. Colistin Resistance and Molecular Characterization of the Genomes ofFrontiers in cellular and infection microbiology · 2022
    Article
  13. Genetic Characterization of an ST5571 HypervirulentInfection and drug resistance · 2022
    Article
  14. Article
  15. Article
  16. Plasmid MediatedFrontiers in microbiology · 2021
    Article
  17. Molecular Mechanisms of Colistin Resistance inFrontiers in cellular and infection microbiology · 2021
    Article
  18. Article
  19. Genomic Characterization ofFrontiers in microbiology · 2021
    Article
  20. Frontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Miriam R FernandesDepartment of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil miriamrfernandes@usp.br lincopan@usp.br.
John A McCullochDepartment of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Marco A VianelloHospital de Guarnição de Natal, Brazilian Army, Natal, Brazil.
Quézia MouraDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Paula J Pérez-ChaparroDepartment of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Fernanda EspositoDepartment of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Luciana SartoriDepartment of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Milena DropaSchool of Public Health, University of São Paulo, São Paulo, Brazil.
Maria H MattéSchool of Public Health, University of São Paulo, São Paulo, Brazil.
Débora P A LiraHospital de Guarnição de Natal, Brazilian Army, Natal, Brazil.
Elsa M MamizukaDepartment of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Nilton LincopanDepartment of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil miriamrfernandes@usp.br lincopan@usp.br.ORCID 0000-0003-0161-5800

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A colistin-resistant Escherichia coli strain was recovered from a patient with a diabetic foot infection in Brazil. Whole-genome analysis revealed that the E. coli isolate belonged to the widespread sequence type (ST) 101 and harbored the mcr-1 gene on an IncX4 plasmid that was highly similar to mcr-1-bearing IncX4 plasmids that were recently identified in Enterobacteriaceae from food, animal, and human samples recovered on different continents. These results suggest that self-transmissible IncX4-type plasmids may represent promiscuous plasmids contributing to the intercontinental spread of the mcr-1 gene.

Indexed as

AgedBrazilColistinDrug Resistance, BacterialEscherichia coliEscherichia coli InfectionsEscherichia coli ProteinsHumansMaleMicrobial Sensitivity TestsPlasmidsColistinEscherichia coli ProteinsMCR-1 protein, E coli

Identifiers

PMID27503650
PMCPMC5038249

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.