Evidence map›Paper›PMID 27503438›Full record

Observational studyJournal of general internal medicine2017

Vital Signs Are Still Vital: Instability on Discharge and the Risk of Post-Discharge Adverse Outcomes.

Oanh Kieu Nguyen, Anil N Makam, Christopher Clark, Song Zhang, Bin Xie, Ferdinand Velasco, Ruben Amarasingham, Ethan A Halm

Open access · bronzeAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Journal of general internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 65 citations in OpenAlex.

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  18. Systems for recognition and response to deteriorating emergency department patients: a scoping review.Scandinavian journal of trauma, resuscitation and emergency medicine · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Oanh Kieu NguyenDivision of General Internal Medicine, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA. OanhK.Nguyen@UTSouthwestern.edu.
Anil N MakamDivision of General Internal Medicine, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Christopher ClarkOffice of Research Administration, Parkland Health & Hospital System, Dallas, TX, USA.
Song ZhangDivision of Biostatistics, Department of Clinical Sciences, UT Southwestern Medical Center, Dallas, TX, USA.
Bin XiePCCI, Dallas, TX, USA.
Ferdinand VelascoTexas Health Resources, Dallas, TX, USA.
Ruben AmarasinghamDivision of General Internal Medicine, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Ethan A HalmDivision of General Internal Medicine, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Parkland Center For Clinical Innovation · USSouthwestern Medical Center · USThe University of Texas Southwestern Medical Center · USParkland Health & Hospital System · USTexas Health Resources Foundation · US

Funding

UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
UT Southwestern Center of Patient-Centered Outcomes Research (PCOR)R24HS022418 · AHRQ · UT SOUTHWESTERN MEDICAL CENTER · PI HALM, ETHAN A · 2013 to 2017
$5.0M
UT Southwestern Center for Translational Medicine (UL1/KL2/TL1KL2TR001103 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$4.0M
AHRQ HHS R24 HS022418NCATS NIH HHS KL2 TR001103NCATS NIH HHS UL1 TR001105
6 · The paper itself

Abstract

backgroundVital sign instability on discharge could be a clinically objective means of assessing readiness and safety for discharge; however, the association between vital sign instability on discharge and post-hospital outcomes is unclear.

objectiveTo assess the association between vital sign instability at hospital discharge and post-discharge adverse outcomes.

designMulti-center observational cohort study using electronic health record data. Abnormalities in temperature, heart rate, blood pressure, respiratory rate, and oxygen saturation were assessed within 24 hours of discharge. We used logistic regression adjusted for predictors of 30-day death and readmission.

participantsAdults (≥18 years) with a hospitalization to any medicine service in 2009-2010 at six hospitals (safety-net, community, teaching, and non-teaching) in north Texas. MAIN MEASURES: Death or non-elective readmission within 30 days after discharge. KEY

resultsOf 32,835 individuals, 18.7 % were discharged with one or more vital sign instabilities. Overall, 12.8 % of individuals with no instabilities on discharge died or were readmitted, compared to 16.9 % with one instability, 21.2 % with two instabilities, and 26.0 % with three or more instabilities (p < 0.001). The presence of any (≥1) instability was associated with higher risk-adjusted odds of either death or readmission (AOR 1.36, 95 % CI 1.26-1.48), and was more strongly associated with death (AOR 2.31, 95 % CI 1.91-2.79). Individuals with three or more instabilities had nearly fourfold increased odds of death (AOR 3.91, 95 % CI 1.69-9.06) and increased odds of 30-day readmission (AOR 1.36, 95 % 0.81-2.30) compared to individuals with no instabilities. Having two or more vital sign instabilities at discharge had a positive predictive value of 22 % and positive likelihood ratio of 1.8 for 30-day death or readmission.

conclusionsVital sign instability on discharge is associated with increased risk-adjusted rates of 30-day mortality and readmission. These simple vital sign criteria could be used to assess safety for discharge, and to reduce 30-day mortality and readmissions.

Indexed as

Outcome Assessment, Health CareAdultAgedChi-Square DistributionCohort StudiesFemaleHospitalsHumansLogistic ModelsMaleMiddle AgedOdds RatioPatient DischargePatient ReadmissionRisk FactorsVital Signs

Identifiers

PMID27503438
PMCPMC5215152
OpenAlexW2505941899

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.