ArticleScientific reports2016
Effects of race and sex on cerebral hemodynamics, oxygen delivery and blood flow distribution in response to high altitude.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Hemodynamic variations in resting-state cerebral functional networks between Tibetan and Han male athletes assessed by fNIRS.Scientific reports · 2026Article
- Pulsatile Hemodynamics of Prehypertension and Hypertension: Associations with Pressure and Sex.Annals of biomedical engineering · 2026Article
- Cerebrovascular autoregulation in hypoxia: quantitative insights from arterial spin labeling.Frontiers in neuroscience · 2025Review
- Relationship between chronic hypoxia and seizure susceptibility.CNS neuroscience & therapeutics · 2022Review
- Review
- Cerebral Blood Flow, Oxygen Delivery, and Pulsatility Responses to Oxygen Inhalation at High Altitude: Highlanders vs. Lowlanders.Frontiers in physiology · 2019Article
- Investigating structural and perfusion deficits due to repeated head trauma in active professional fighters.NeuroImage. Clinical · 2018Article
- Measuring high-altitude adaptation.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- UBC-Nepal expedition: markedly lower cerebral blood flow in high-altitude Sherpa children compared with children residing at sea level.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess racial, sexual, and regional differences in cerebral hemodynamic response to high altitude (HA, 3658 m). We performed cross-sectional comparisons on total cerebral blood flow (TCBF = sum of bilateral internal carotid and vertebral arterial blood flows = QICA + QVA), total cerebrovascular resistance (TCVR), total cerebral oxygen delivery (TCOD) and QVA/TCBF (%), among six groups of young healthy subjects: Tibetans (2-year staying) and Han (Han Chinese) at sea level, Han (2-day, 1-year and 5-year) and Tibetans at HA. Bilateral ICA and VA diameters and flow velocities were derived from duplex ultrasonography; and simultaneous measurements of arterial pressure, oxygen saturation, and hemoglobin concentration were conducted. Neither acute (2-day) nor chronic (>1 year) responses showed sex differences in Han, except that women showed lower TCOD compared with men. Tibetans and Han exhibited different chronic responses (percentage alteration relative to the sea-level counterpart value) in TCBF (-17% vs. 0%), TCVR (22% vs. 12%), TCOD (0% vs. 10%) and QVA/TCBF (0% vs. 2.4%, absolute increase), with lower resting TCOD found in SL- and HA-Tibetans. Our findings indicate racial but not sex differences in cerebral hemodynamic adaptations to HA, with Tibetans (but not Han) demonstrating an altitude-related change of CBF distribution.
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