ArticleJournal of diabetes and its complications2017
Ten-year hemoglobin A1c trajectories and outcomes in type 2 diabetes mellitus: The Diabetes & Aging Study.
Article in Journal of diabetes and its complications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Longitudinal trends in HbADiabetes/metabolism research and reviews · 2018Pooled it
- Model-Informed Approaches for Pediatric Type 2 Diabetes Evidence Generation: Insights from a Model-Based Longitudinal HbA1c Meta-Analysis from EMA Marketing Authorization Applications.Clinical pharmacology and therapeutics · 2026Article
- Early identification of suboptimal responders to metformin in type 2 diabetes using long-term real-world HbA1c trajectories.medRxiv : the preprint server for health sciences · 2026Article
- Humor Training and Diabetes: An Adjunct to Treatment.American journal of lifestyle medicine · 2026Article
- Negative descriptors in electronic health records of patients with diabetes.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Latent class growth mixture modeling of HbA1C trajectories identifies individuals at high risk of developing complications of type 2 diabetes mellitus in the UK Biobank.BMJ open diabetes research & care · 2025Article
- Glycaemic and Weight Control in People Aged 65 or Younger Newly Diagnosed with Type 2 Diabetes in Spain: Insights from the PRIORITY-T2D Study.Advances in therapy · 2025Observational
- Effects of the leisure-time physical activity environment on odds of glycemic control among a nationwide cohort of United States veterans with a new type-2 diabetes diagnosis.Preventive medicine · 2025Article
- Association between estimated glucose disposal rate and major adverse cardiovascular events in patients with type 2 diabetes.PloS one · 2025Article
- Prospects for the convergence of polyphenols with pharmaceutical drugs in type 2 diabetes: Challenges, risks, and strategies.Pharmacological reviews · 2025Review
- Modeling recurrent heart failure risk in type 2 diabetes: impact of flexible HbA1c trajectories using nonhomogeneous Poisson processes.Frontiers in endocrinology · 2025Article
- TSH Trajectories During Levothyroxine Treatment in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Cohort.The Journal of clinical endocrinology and metabolism · 2024Article
- The role of glycemic traits in the mediation of the causal effect of hypothyroidism on coronary heart disease.Frontiers in endocrinology · 2024Article
- Risk factors associated with glycated hemoglobin A1c trajectories progressing to type 2 diabetes.Annals of medicine · 2023Article
- Longitudinal trajectories of glycemic control among U.S. Adults with newly diagnosed diabetes.Diabetes research and clinical practice · 2023Article
- Glycemic control, HbA1c variability, and major cardiovascular adverse outcomes in type 2 diabetes patients with elevated cardiovascular risk: insights from the ACCORD study.Cardiovascular diabetology · 2023Article
- Measuring continuity of care for diabetes: which visits to include?The American journal of managed care · 2023Article
- Association of hemoglobin A1c stability with mortality and diabetes complications in older adults with diabetes.BMJ open diabetes research & care · 2023Observational
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
aimsTo classify trajectories of long term HbA1c values in patients after diagnosis of type 2 diabetes and examine each trajectory's associations with subsequent microvascular and macrovascular events and mortality.
methodsA longitudinal follow-up of 28,016 patients newly diagnosed with type 2 diabetes was conducted. Latent growth mixture modeling was used to identify ten-year HbA1c trajectories. Cox proportional hazards models were used to assess how HbA1c trajectories were associated with events (microvascular and macrovascular) and mortality.
resultsWe identified 5 HbA1c trajectories: "low stable" (82.5%), "moderate increasing late" (5.1%), "high decreasing early" (4.9%), "moderate peaking late" (4.1%) and "moderate peaking early" (3.3%). After adjusting for average HbA1c, compared to the low stable trajectory, all non-stable trajectories were associated with higher incidences of microvascular events (hazard ratio (HR) range, 1.28 (95% CI, 1.08-1.53) (high decreasing early) to 1.45 (95% CI, 1.20-1.75) (moderate peaking early)). The high decreasing early trajectory was associated with an increased mortality risk (HR, 1.27 (95% CI, 1.03-1.58)). Trajectories were not associated with macrovascular events.
conclusionsNon-stable HbA1c trajectories were associated with greater risk of microvascular events and mortality. These findings suggest a potential benefit of early diabetes detection, prioritizing good glycemic control, and maintaining control over time.
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