ArticleBrain connectivity2016
Resting-state functional connectivity by independent component analysis-based markers corresponds to areas of initial seizure propagation established by prior modalities from the hypothalamus.
Article in Brain connectivity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Precision connectivity in osteoarthritis pain with permutation and network analysis: a key step toward clinical application.BMC medical imaging · 2025Article
- Precision Connectivity in Arthritis Pain with Permutation and Network Analysis: A Key Step Toward Clinical Application.Research square · 2025Article
- Distinct gray matter and metabolic characteristics in hypothalamic hamartoma network with different semiology.Epilepsia · 2025Article
- Resting-state functional MRI in pediatric epilepsy: a narrative review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Advances in epileptic network findings of hypothalamic hamartomas.Journal of central nervous system disease · 2024Review
- Unified topological inference for brain networks in temporal lobe epilepsy using the Wasserstein distance.NeuroImage · 2023Article
- Treatable brain network biomarkers in children in coma using task and resting-state functional MRI: a case series.Frontiers in neurology · 2023Article
- Discerning Seizure-Onset v. Propagation Zone: Pre-and-Post-Operative Resting-State fMRI Directionality and Boerwinkle Neuroplasticity Index.NeuroImage. Clinical · 2022Article
- Hypothalamic Hamartomas: Evolving Understanding and Management.Neurology · 2021Review
- Resting State Functional Magnetic Resonance Imaging Elucidates Neurotransmitter Deficiency in Autism Spectrum Disorder.Journal of personalized medicine · 2021Article
- Locked-in Intact Functional Networks in Children with Autism Spectrum Disorder: A Case-Control Study.Journal of personalized medicine · 2021Article
- Lesion Network Localization of Seizure Freedom following MR-guided Laser Interstitial Thermal Ablation.Scientific reports · 2019Article
- Emotional Prosody Processing in Epilepsy: Some Insights on Brain Reorganization.Frontiers in human neuroscience · 2018Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aims of this study were to evaluate a clinically practical functional connectivity protocol designed to blindly identify the corresponding areas of initial seizure propagation and also to differentiate these areas from remote secondary areas affected by seizure. The patients in this cohort had intractable epilepsy caused by intrahypothalamic hamartoma, which is the location of the ictal focus. The ictal propagation pathway is homogeneous and established, thus creating the optimum situation for the proposed method validation study.
methodsTwelve patients with seizures from hypothalamic hamartoma and 6 normal control patients underwent resting state functional MRI, using independent component analysis to identify network differences in patients. This was followed by seed-based connectivity measures to determine the extent of functional connectivity derangement between hypothalamus and these areas. The areas with significant change in connectivity were compared with the results of prior studies' modalities used to evaluate seizure propagation.
resultsThe left amygdala-parahippocampal gyrus area, cingulate gyrus, and occipito-temporal gyrus demonstrated the highest derangement in connectivity with the hypothalamus, p < 0.01, corresponding to the initial seizure propagation areas established by prior modalities. Areas of secondary ictal propagation were differentiated from these initial locations by first being identified as an abnormal neuronal signal source via independent component analysis, but did not show significant connectivity directly with the known ictal focus.
conclusionNon-invasive connectivity measures correspond to areas of initial ictal propagation and differentiate such areas from secondary ictal propagation, which may aid in ictal focus surgical disconnection planning and support the use of this newer modality for adjunctive information in epilepsy surgery evaluation.
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