Evidence map›Paper›PMID 27503232›Full record

ArticleThorax2017

The obstructive sleep apnoea syndrome in adolescents.

Carole L Marcus, Brendan T Keenan, Jingtao Huang, Haibo Yuan, Swaroop Pinto, Ruth M Bradford, Christopher Kim, Sheila Bagchi, Francois-Louis Comyn, Stephen Wang and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Thorax, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Upper Airway Volume Predicts Brain Structure and Cognition in Adolescents.American journal of respiratory and critical care medicine · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Carole L MarcusSleep Center, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Brendan T KeenanCenter for Sleep & Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jingtao HuangSleep Center, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Haibo YuanSleep Center, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Swaroop PintoSleep Center, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ruth M BradfordSleep Center, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Christopher KimCenter for Sleep & Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sheila BagchiCenter for Sleep & Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Francois-Louis ComynCenter for Sleep & Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Stephen WangCenter for Sleep & Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ignacio E TapiaSleep Center, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Greg MaislinCenter for Sleep & Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Christopher M CieloSleep Center, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Joel TraylorSleep Center, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Drew A TorigianDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Richard J SchwabCenter for Sleep & Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USPhiladelphia University · USJilin University · CN

Funding

Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Understanding the relationship between obesity and tongue fat in humans and ratsP01HL094307 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I · 2009 to 2020
$23.7M
Institutional Clinical and Translational Science AwardKL2TR001879 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$13.7M
PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEAR01HL058585 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MARCUS, CAROLE L · 1998 to 2012
$4.3M
Obesity & OSA: Understanding the Importance of Tongue Fat and Metabolic FunctionR01HL089447 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SCHWAB, RICHARD J. · 2008 to 2011
$2.4M
Pathophysiology of Childhood Obstructive Sleep ApneaR56HL058585 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI MARCUS, CAROLE L · 2008 to 2008
$500k
NCATS NIH HHS KL2 TR001879NCATS NIH HHS UL1 TR000003NHLBI NIH HHS P01 HL094307NHLBI NIH HHS R01 HL058585NHLBI NIH HHS R01 HL089447NHLBI NIH HHS R56 HL058585
6 · The paper itself

Abstract

backgroundThe obstructive sleep apnoea syndrome (OSAS) results from a combination of structural and neuromotor factors; however, the relative contributions of these factors have not been studied during the important developmental phase of adolescence. We hypothesised that adenotonsillar volume (ATV), nasopharyngeal airway volume (NPAV), upper airway critical closing pressure (Pcrit) in the hypotonic and activated neuromotor states, upper airway electromyographic response to subatmospheric pressure and the ventilatory response to CO

methods42 obese adolescents with OSAS and 37 weight-matched controls underwent upper airway MRI, measurements of Pcrit, genioglossal electromyography and ventilatory response to CO

resultsATV, NPAV, activated and hypotonic Pcrit, genioglossal electromyography and ventilatory response to CO

conclusionsOSAS in adolescents is mediated by a combination of anatomic (ATV, NPAV) and neuromotor factors (activated Pcrit). This may have important implications for the management of OSAS in adolescents.

Indexed as

AdolescentChildElectromyographyFemaleHumansMagnetic Resonance ImagingMaleObesityPalate, SoftPolysomnographySleepSleep Apnea, ObstructiveSleep apnoea

Identifiers

PMID27503232
PMCPMC9277419
OpenAlexW2476657891

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.