Evidence map›Paper›PMID 27503223›Full record

ArticleBioinformatics (Oxford, England)2016

Bayesian network feature finder (BANFF): an R package for gene network feature selection.

Zhou Lan, Yize Zhao, Jian Kang, Tianwei Yu

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Synthetic data generation with probabilistic Bayesian Networks.Mathematical biosciences and engineering : MBE · 2021
    Article
  5. Probabilistic Graphical Models Applied to Biological Networks.Advances in experimental medicine and biology · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhou LanDepartment of Statistics, North Carolina State University, Raleigh, NC 27695-8203, USA.
Yize ZhaoDepartment of Healthcare Policy and Research, Weill Cornell Medical College, New York, NY 10065, USA.
Jian KangDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109-2029, USA.
Tianwei YuDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA.

Funding

Systems Biological Analysis of Innate and Adaptive Responses to VaccinationU19AI090023 · NIAID · EMORY UNIVERSITY · PI MULLIGAN, MARK JOSEPH · 2010 to 2021
$45.0M
Statistical ICA Methods for Analysis & Integration of Multi-dimensional Data Diversity SupplementR01MH105561 · NIMH · EMORY UNIVERSITY · PI GUO, YING, KANG, JIAN · 2014 to 2024
$4.3M
Emory R38 Research Training ProgramR38AI140299 · NIAID · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, ROUPHAEL, NADINE GEORGES · 2018 to 2021
$1.4M
NIAID NIH HHS R38 AI140299NIAID NIH HHS U19 AI090023NIMH NIH HHS R01 MH105561
6 · The paper itself

Abstract

motivationNetwork marker selection on genome-scale networks plays an important role in the understanding of biological mechanisms and disease pathologies. Recently, a Bayesian nonparametric mixture model has been developed and successfully applied for selecting genes and gene sub-networks. Hence, extending this method to a unified approach for network-based feature selection on general large-scale networks and creating an easy-to-use software package is on demand.

resultsWe extended the method and developed an R package, the Bayesian network feature finder (BANFF), providing a package of posterior inference, model comparison and graphical illustration of model fitting. The model was extended to a more general form, and a parallel computing algorithm for the Markov chain Monte Carlo -based posterior inference and an expectation maximization-based algorithm for posterior approximation were added. Based on simulation studies, we demonstrate the use of BANFF on analyzing gene expression on a protein-protein interaction network. AVAILABILITY: https://cran.r-project.org/web/packages/BANFF/index.html CONTACT: jiankang@umich.edu, tianwei.yu@emory.eduSupplementary information: Supplementary data are available at Bioinformatics online.

Indexed as

Bayes TheoremGene Regulatory NetworksSoftwareAlgorithmsComputational BiologyHumansMarkov Chains

Identifiers

PMID27503223
PMCPMC5181536

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.