ArticleScientific reports2016
Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Temporal trends in equine sperm progressive motility: a systematic review and meta-regression.Reproduction (Cambridge, England) · 2023Pooled it
- Laterality and Breed Distribution of Cryptorchidism in 251 Dogs: A Retrospective Clinical Study.Veterinary sciences · 2026Article
- Transgenerational Impact of Environmental Change.Advances in experimental medicine and biology · 2026Review
- Temporal Changes in Indicators of Testicular Dysgenesis Syndrome in Labrador and Golden Retrievers.Animals : an open access journal from MDPI · 2025Article
- Per- and polyfluoroalkyl substances in dog blood serum levels and semen quality.Frontiers in endocrinology · 2025Article
- Rapid identification of reproductive toxicants among environmental chemicals using an in vivo evaluation of gametogenesis in budding yeast Saccharomyces cerevisiae.Reproductive toxicology (Elmsford, N.Y.) · 2024Article
- Redox mechanisms of environmental toxicants on male reproductive function.Frontiers in cell and developmental biology · 2024Review
- Effects of preconception exposure to phthalates on mouse sperm capacitation parameters.Andrology · 2023Article
- Potential Function of Testicular MicroRNAs in Heat-Stress-Induced Spermatogenesis Disorders.International journal of molecular sciences · 2023Article
- Endocrine-Disrupting Chemicals and Their Effects in Pet Dogs and Cats: An Overview.Animals : an open access journal from MDPI · 2023Review
- Endocrine disrupting chemicals and male fertility: from physiological to molecular effects.Frontiers in public health · 2023Review
- Reproductive Management in Catteries: Optimising health and wellbeing through veterinarian-breeder collaboration.Journal of feline medicine and surgery · 2022Review
- Modeling di (2-ethylhexyl) Phthalate (DEHP) and Its Metabolism in a Body's Organs and Tissues through Different Intake Pathways into Human Body.International journal of environmental research and public health · 2022Article
- Chronic Immune-Mediated Orchitis Is the Major Cause of Acquired Non-obstructive Azoospermia in Dogs.Frontiers in veterinary science · 2022Article
- Phthalate Toxicity in Rats and Its Relation to Testicular Dysgenesis Syndrome in Humans.Toxicologic pathology · 2021Article
- Systematic Analysis of Breed, Methodological, and Geographical Impact on Equine Sperm Progressive Motility.Animals : an open access journal from MDPI · 2021Review
- Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology.Scientific reports · 2021Article
- Companion animals get close to the toxic aspects of antropogenic world: cytotoxicity of phthalates and bisphenol A on dog testicular primary cells.Cytotechnology · 2020Article
- Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research.Environmental science & technology · 2020Article
- Independent and combined effects of diethylhexyl phthalate and polychlorinated biphenyl 153 on sperm quality in the human and dog.Scientific reports · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse temporal trends in human semen quality and cryptorchidism in infants have been associated with exposure to environmental chemicals (ECs) during development. Here we report that a population of breeding dogs exhibit a 26 year (1988-2014) decline in sperm quality and a concurrent increased incidence of cryptorchidism in male offspring (1995-2014). A decline in the number of males born relative to the number of females was also observed. ECs, including diethylhexyl phthalate (DEHP) and polychlorinated biphenyl 153 (PCB153), were detected in adult dog testes and commercial dog foods at concentrations reported to perturb reproductive function in other species. Testicular concentrations of DEHP and PCB153 perturbed sperm viability, motility and DNA integrity in vitro but did not affect LH stimulated testosterone secretion from adult testis explants. The direct effects of chemicals on sperm may therefore contribute to the decline in canine semen quality that parallels that reported in the human.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.