Evidence map›Paper›PMID 27503080›Full record

ArticleMedical image analysis2016

Quantitative analysis of retinal OCT.

Milan Sonka, Michael D Abràmoff

Abstract readEditorial
In one paragraph

Article in Medical image analysis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 58 citations in OpenAlex.

  1. Octascope: A Lightweight Pre-Trained Model for Optical Coherence Tomography.IEEE access : practical innovations, open solutions · 2025
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  15. Retinal vessel optical coherence tomography images for anemia screening.Medical & biological engineering & computing · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Milan SonkaIowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA 52242, United States; Department of Ophthalmology & Visual Sciences, The University of Iowa, Iowa City, IA 52242, United States; Department of Electrical & Computer Engineering, The University of Iowa, Iowa City, IA 52242, United States . Electronic address: milan-sonka@uiowa.edu.
Michael D AbràmoffIowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA 52242, United States; Department of Ophthalmology & Visual Sciences, The University of Iowa, Iowa City, IA 52242, United States; Department of Electrical & Computer Engineering, The University of Iowa, Iowa City, IA 52242, United States.
University of Iowa · US

Funding

Graph-Based Medical Image Segmentation in 3D and 4DR01EB004640 · NIBIB · UNIVERSITY OF IOWA · PI BUATTI, JOHN M, SONKA, MILAN · 2006 to 2022
$6.1M
Retinal Therapy Guided by 3-D OCT Image AnalysisR01EY019112 · NEI · UNIVERSITY OF IOWA · PI ABRAMOFF, MICHAEL DAVID, SONKA, MILAN · 2010 to 2014
$2.6M
Three-dimensional structure-function relationships in glaucoma from SD-OCTR01EY018853 · NEI · UNIVERSITY OF IOWA · PI ABRAMOFF, MICHAEL DAVID, KWON, YOUNG H. · 2009 to 2016
$2.6M
Low-cost, portable, computer assisted imaging for diabe*R01EY017066 · NEI · UNIVERSITY OF IOWA · PI ABRAMOFF, MICHAEL DAVID · 2005 to 2008
$1.3M
CSRD VA I01 CX000119NEI NIH HHS R01 EY017066NEI NIH HHS R01 EY018853NEI NIH HHS R01 EY019112NIBIB NIH HHS R01 EB004640RRD VA I21 RX001084
6 · The paper itself

Abstract

Clinical acceptance of 3-D OCT retinal imaging brought rapid development of quantitative 3-D analysis of retinal layers, vasculature, retinal lesions as well as facilitated new research in retinal diseases. One of the cornerstones of many such analyses is segmentation and thickness quantification of retinal layers and the choroid, with an inherently 3-D simultaneous multi-layer LOGISMOS (Layered Optimal Graph Image Segmentation for Multiple Objects and Surfaces) segmentation approach being extremely well suited for the task. Once retinal layers are segmented, regional thickness, brightness, or texture-based indices of individual layers can be easily determined and thus contribute to our understanding of retinal or optic nerve head (ONH) disease processes and can be employed for determination of disease status, treatment responses, visual function, etc. Out of many applications, examples provided in this paper focus on image-guided therapy and outcome prediction in age-related macular degeneration and on assessing visual function from retinal layer structure in glaucoma.

Indexed as

Tomography, Optical CoherenceAlgorithmsGlaucomaHumansImaging, Three-DimensionalMacular DegenerationRetinaChoroidLOGISMOSOptical coherence tomography (OCT)Quantitative medical imagingRetinaVisual function

Identifiers

PMID27503080
PMCPMC13671394
OpenAlexW2475095287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.