SynthesisNeuroscience and biobehavioral reviews2016
Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives: A review of the literature.
Synthesis in Neuroscience and biobehavioral reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mindfulness-based cognitive therapy for bipolar disorder: A systematic review.Journal of affective disorders · 2018Pooled it
- Pooled it
- Associations of TNF-α, MIF, and cortisol with cognitive function in patients with bipolar disorder during acute manic episodes: a short-term follow-up study.Frontiers in psychiatry · 2026Article
- Gut microbiota links to cognitive impairment in bipolar disorder via modulating synaptic plasticity.BMC medicine · 2025Article
- Psychosis and diving.Diving and hyperbaric medicine · 2025Review
- Independent inheritance of cognition and bipolar disorder in a family sample.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025Article
- The Impact of Electrophysiological Diversity on Pattern Completion in Lithium Nonresponsive Bipolar Disorder: A Computational Modeling Approach.Brain and behavior · 2025Article
- Bridging big data in the ENIGMA consortium to combine non-equivalent cognitive measures.Scientific reports · 2024Article
- Inflammatory Biomarkers, Cognitive Functioning, and Brain Imaging Abnormalities in Bipolar Disorder: A Systematic Review.Clinical neuropsychiatry · 2024Review
- Can neurological soft signs and neurocognitive deficits serve as a combined endophenotype for Han Chinese with bipolar disorder?International journal of methods in psychiatric research · 2023Article
- Processing speed - A potential candidate cognitive endophenotype for bipolar disorder.Journal of affective disorders reports · 2023Article
- Validity of remote administration of the MATRICS Consensus Cognitive Battery for individuals with severe mental illness.Schizophrenia research. Cognition · 2022Article
- Association of Lithium and Second-Generation Antipsychotics with Neurocognition in Youth with Bipolar Disorder.Journal of child and adolescent psychopharmacology · 2022Article
- Cognitive profiles in bipolar I disorder and associated risk factors: Using Wechsler adult intelligence scale-IV.Frontiers in psychology · 2022Article
- Calcium imaging reveals depressive- and manic-phase-specific brain neural activity patterns in a murine model of bipolar disorder: a pilot study.Translational psychiatry · 2021Article
- Protocol for magnetic resonance imaging acquisition, quality assurance, and quality check for the Accelerator program for Discovery in Brain disorders using Stem cells.International journal of methods in psychiatric research · 2021Article
- Symptoms of traumatic encephalopathy syndrome are common in the US general population.Brain communications · 2021Article
- Neurocognitive functioning in bipolar disorder: What we know and what we don't.Dialogues in clinical neuroscience · 2021Review
- The genetics of bipolar disorder.Molecular psychiatry · 2020Review
- Altered Functional Integration in the Salience and Default Mode Networks in Euthymic Pediatric Bipolar Disorder.Neural plasticity · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundNeurocognitive deficits are present in bipolar disorder (BD) patients and their unaffected (nonbipolar) relatives, but it is not clear which domains are most often impaired and the extent of the impairment resulting from shared genetic factors. In this literature review, we address these issues and identify specific neurocognitive tasks most sensitive to cognitive deficits in patients and unaffected relatives.
methodWe conducted a systematic review in Web of Science, PubMed/Medline and PsycINFO databases.
resultsFifty-one articles assessing cognitive functioning in BD patients (23 studies) and unaffected relatives (28 studies) were examined. Patients and, less so, relatives show impairments in attention, processing speed, verbal learning/memory, and verbal fluency.
conclusionStudies were more likely to find impairment in patients than relatives, suggesting that some neurocognitive deficits may be a result of the illness itself and/or its treatment. However, small sample sizes, differences among relatives studied (e.g., relatedness, diagnostic status, age), and differences in assessment instruments may contribute to inconsistencies in reported neurocognitive performance among relatives. Additional studies addressing these issues are needed.
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