ArticleNanoscale research letters2011
Enhanced Specificity of Multiplex Polymerase Chain Reaction via CdTe Quantum Dots.
Article in Nanoscale research letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The nucleic acid reactions on the nanomaterials surface for biomedicine.Journal of nanobiotechnology · 2025Review
- Nanotechnology-Enabled PCR with Tunable Energy Dynamics.JACS Au · 2024Review
- Facilitation of Dye-Based Quantitative Real-Time Polymerase Chain Reaction with Poly(ethylene glycol)-Engrafted Graphene Oxide.Nanomaterials (Basel, Switzerland) · 2023Article
- Enhancement of the polymerase chain reaction by tungsten disulfide.RSC advances · 2019Article
- State-of-the-Art and Trends in Synthesis, Properties, and Application of Quantum Dots-Based Nanomaterials.Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems · 2019Article
- Formation Mechanism and Dispersion of Pseudo-Tetragonal BaTiO₃-PVP Nanoparticles from Different Titanium Precursors: TiCl₄ and TiO₂.Materials (Basel, Switzerland) · 2017Article
- CdTe quantum dots enhance feasibility of EvaGreen-based real-time PCR with decent amplification fidelity.Molecular biotechnology · 2013Article
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Authors and funding
7 authors.
Funding
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Abstract
Nanoparticles were recently reported to be able to improve both efficiency and specificity in polymerase chain reaction (PCR). Here, CdTe QDs were introduced into multi-PCR systems. It was found that an appropriate concentration of CdTe QDs could enhance the performance of multi-PCR by reducing the formation of nonspecific products in the complex system, but an excessive amount of CdTe QDs could suppress the PCR. The effects of QDs on PCR can be reversed by increasing the polymerase concentration or by adding bovine serum albumin (BSA). The mechanisms underlying these effects were also discussed. The results indicated that CdTe QDs could be used to optimize the amplification products of the PCR, especially in the multi-PCR system with different primers annealing temperatures, which is of great significance for molecular diagnosis.
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