ArticleNanoscale research letters2011
Facile Synthesis of Amine-Functionalized Eu(3+)-Doped La(OH)3 Nanophosphors for Bioimaging.
Article in Nanoscale research letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Control of Particle Size in Flame Spray Pyrolysis of Tb-doped YMaterials (Basel, Switzerland) · 2020Article
- Cone Beam X-ray Luminescence Computed Tomography Based on Bayesian Method.IEEE transactions on medical imaging · 2017Article
- Oxidative stress response in neural stem cells exposed to different superparamagnetic iron oxide nanoparticles.International journal of nanomedicine · 2016Article
- Cerenkov luminescence endoscopy: improved molecular sensitivity with β--emitting radiotracers.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2014Article
- Cytotoxicity, oxidative stress, and genotoxicity in human hepatocyte and embryonic kidney cells exposed to ZnO nanoparticles.Nanoscale research letters · 2012Article
- Radioluminescent nanophosphors enable multiplexed small-animal imaging.Optics express · 2012Article
- Article
- Limited-angle x-ray luminescence tomography: methodology and feasibility study.Physics in medicine and biology · 2011Article
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4 authors.
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Abstract
Here, we report a straightforward synthesis process to produce colloidal Eu(3+)-activated nanophosphors (NPs) for use as bioimaging probes. In this procedure, poly(ethylene glycol) serves as a high-boiling point solvent allowing for nanoscale particle formation as well as a convenient medium for solvent exchange and subsequent surface modification. The La(OH)3:Eu(3+) NPs produced by this process were ~3.5 nm in diameter as determined by transmission electron microscopy. The NP surface was coated with aminopropyltriethoxysilane to provide chemical functionality for attachment of biological ligands, improve chemical stability and prevent surface quenching of luminescent centers. Photoluminescence spectroscopy of the NPs displayed emission peaks at 597 and 615 nm (λex = 280 nm). The red emission, due to (5)D0 → (7)F1 and (5)D0 → (7)F2 transitions, was linear with concentration as observed by imaging with a conventional bioimaging system. To demonstrate the feasibility of these NPs to serve as optical probes in biological applications, an in vitro experiment was performed with HeLa cells. NP emission was observed in the cells by fluorescence microscopy. In addition, the NPs displayed no cytotoxicity over the course of a 48-h MTT cell viability assay. These results suggest that La(OH)3:Eu(3+) NPs possess the potential to serve as a luminescent bioimaging probe.
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