ArticleNanoscale research letters2011
Biocompatibility of Graphene Oxide.
Article in Nanoscale research letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 258 papers, 1 of them a synthesis that pooled it.
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Who cites it
258 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,045 citations in OpenAlex.
- Recent Advances in Graphene Oxide-Based on Organoid Culture as Disease Model and Cell Behavior - A Systematic Literature Review.International journal of nanomedicine · 2024Pooled it
- Integrated assessment of graphene oxide and graphitic carbon nitride nanoparticles: from synthesis to in vitro biological impact on zebrafish (Danio rerio) cell models.In vitro cellular & developmental biology. Animal · 2026Article
- Cell Toxicity and Autophagy in A549 Cells Treated With Surface-Functionalized Graphene Derivatives.Journal of applied toxicology : JAT · 2026Article
- Selenium-modified graphene oxide: A tri-dimensional study of its cytotoxicity and developmental effects.Materials today. Bio · 2026Article
- Response to multigenerational graphene oxide exposure in acheta domesticus strains selected for longevity.Scientific reports · 2026Article
- Structural and biological characterization of carbon-graphene biomaterials derived from black liquor with functional properties for bone tissue engineering.Scientific reports · 2025Article
- Modulating Schwann cell behavior via functional nerve guidance conduits for enhanced peripheral nerve regeneration.NPJ Regenerative medicine · 2025Review
- Graphene Oxide: Preparation and Medical Research.Materials (Basel, Switzerland) · 2025Review
- Exploring 2D Graphene-Based Nanomaterials for Biomedical Applications: A Theoretical Modeling Perspective.Small science · 2025Article
- Modification of low nickel biograde stainless steel with graphene oxide for enhanced corrosion resistance and in vivo biocompatibility.Scientific reports · 2025Article
- The Role and Future of Functional Graphenic Materials in Biomedical and Human Health Applications.Biomacromolecules · 2025Review
- Graphene-based materials: an innovative approach for neural regeneration and spinal cord injury repair.RSC advances · 2025Review
- From conventional to cutting edge: an exploration of osteosarcoma treatments.Medical oncology (Northwood, London, England) · 2025Review
- Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro Model.International journal of nanomedicine · 2025Article
- Research on the impact of graphene oxide in feed on growth and health parameters in calves.Frontiers in toxicology · 2025Article
- Application of the Tier 3 NIOSH occupational exposure banding process for the graphene family of nanomaterials: A case study.Journal of occupational and environmental hygiene · 2025Article
- Personalized composite scaffolds for accelerated cell- and growth factor-free craniofacial bone regeneration.Bioactive materials · 2024Article
- Potential role of calcium sulfate/β-tricalcium phosphate/graphene oxide nanocomposite for bone graft application_mechanical and biological analyses.Journal of orthopaedic surgery and research · 2024Article
- Ascorbic Acid and Graphene Oxide Exposure in the Model OrganismMolecules (Basel, Switzerland) · 2024Article
- Hydrogel mechanical properties in altered gravity.NPJ microgravity · 2024Article
198 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein, we report the effects of graphene oxides on human fibroblast cells and mice with the aim of investigating graphene oxides' biocompatibility. The graphene oxides were prepared by the modified Hummers method and characterized by high-resolution transmission electron microscope and atomic force microscopy. The human fibroblast cells were cultured with different doses of graphene oxides for day 1 to day 5. Thirty mice divided into three test groups (low, middle, high dose) and one control group were injected with 0.1, 0.25, and 0.4 mg graphene oxides, respectively, and were raised for 1 day, 7 days, and 30 days, respectively. Results showed that the water-soluble graphene oxides were successfully prepared; graphene oxides with dose less than 20 μg/mL did not exhibit toxicity to human fibroblast cells, and the dose of more than 50 μg/mL exhibits obvious cytotoxicity such as decreasing cell adhesion, inducing cell apoptosis, entering into lysosomes, mitochondrion, endoplasm, and cell nucleus. Graphene oxides under low dose (0.1 mg) and middle dose (0.25 mg) did not exhibit obvious toxicity to mice and under high dose (0.4 mg) exhibited chronic toxicity, such as 4/9 mice death and lung granuloma formation, mainly located in lung, liver, spleen, and kidney, almost could not be cleaned by kidney. In conclusion, graphene oxides exhibit dose-dependent toxicity to cells and animals, such as inducing cell apoptosis and lung granuloma formation, and cannot be cleaned by kidney. When graphene oxides are explored for in vivo applications in animal or human body, its biocompatibility must be considered.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.