Evidence map›Paper›PMID 27502399›Full record

ReviewCurrent genetics2017

Size doesn't matter in the heat shock response.

David Pincus

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

David PincusNine Cambridge Center, Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA. pincus@wi.mit.edu.ORCID http://orcid.org/0000-0002-9651-6858
Whitehead Institute for Biomedical Research · US

Funding

Quantitative approaches to reveal the homeostatic control mechanisms of stress reDP5OD017941 · OD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI PINCUS, DAVID · 2013 to 2017
$2.4M
NIH HHS DP5 OD017941
6 · The paper itself

Abstract

Heat shock factor 1 (Hsf1) is a transcription factor that is often described as the master regulator of the heat shock response in all eukaryotes. However, due to its essentiality in yeast, Hsf1's contribution to the transcriptome under basal and heat shock conditions has never been directly determined. Using a chemical genetics approach that allowed rapid Hsf1 inactivation, my colleagues and I have recently shown that the bulk of the heat shock response is Hsf1 independent. Rather than inducing genes responsible for carrying out the various cellular processes required for adaptation to thermal stress, Hsf1 controls a dedicated set of chaperone protein genes devoted to restoring protein-folding homeostasis. The limited scope of the Hsf1 regulon belies its outsize importance in cellular fitness.

Indexed as

Adaptation, PhysiologicalDNA-Binding ProteinsGene Expression Regulation, FungalGenes, EssentialHeat-Shock ProteinsHeat-Shock ResponseHomeostasisSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsDNA-Binding ProteinsHeat-Shock ProteinsHSF1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsChaperonesHeat shockHsf1Hsp70Hsp90Proteostasis

Identifiers

PMID27502399
PMCPMC5298949
OpenAlexW2510294497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.