Evidence map›Paper›PMID 27502247›Full record

SynthesisNeuro-oncology2017

MR perfusion-weighted imaging in the evaluation of high-grade gliomas after treatment: a systematic review and meta-analysis.

Praneil Patel, Hediyeh Baradaran, Diana Delgado, Gulce Askin, Paul Christos, Apostolos John Tsiouris, Ajay Gupta

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuro-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 10 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 10 syntheses or guidelines pooled it, 243 citations in OpenAlex.

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  10. SEOM clinical guidelines for anaplastic gliomas (2017).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018
    Guideline
  11. The Next Frontier in Quantitative Co-Clinical Imaging to Advance Functional Precision Oncology.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. CMROLa Radiologia medica · 2025
    Article
  19. Imaging in Neuro-oncology.Seminars in neurology · 2025
    Review
  20. Article

95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Praneil PatelDepartment of Radiology, Weill Cornell Medical College/New York-Presbyterian Hospital, New York, New York (P.P., H.B., A.J.T., A.G.); Samuel J. Wood Library & C. V. Starr Biomedical Information Center, Weill Cornell Medical College, New York, New York (D.D.); Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, New York (G.A., P.C.) pmp9007@med.cornell.edu.
Hediyeh BaradaranDepartment of Radiology, Weill Cornell Medical College/New York-Presbyterian Hospital, New York, New York (P.P., H.B., A.J.T., A.G.); Samuel J. Wood Library & C. V. Starr Biomedical Information Center, Weill Cornell Medical College, New York, New York (D.D.); Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, New York (G.A., P.C.).
Diana DelgadoDepartment of Radiology, Weill Cornell Medical College/New York-Presbyterian Hospital, New York, New York (P.P., H.B., A.J.T., A.G.); Samuel J. Wood Library & C. V. Starr Biomedical Information Center, Weill Cornell Medical College, New York, New York (D.D.); Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, New York (G.A., P.C.).
Gulce AskinDepartment of Radiology, Weill Cornell Medical College/New York-Presbyterian Hospital, New York, New York (P.P., H.B., A.J.T., A.G.); Samuel J. Wood Library & C. V. Starr Biomedical Information Center, Weill Cornell Medical College, New York, New York (D.D.); Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, New York (G.A., P.C.).
Paul ChristosDepartment of Radiology, Weill Cornell Medical College/New York-Presbyterian Hospital, New York, New York (P.P., H.B., A.J.T., A.G.); Samuel J. Wood Library & C. V. Starr Biomedical Information Center, Weill Cornell Medical College, New York, New York (D.D.); Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, New York (G.A., P.C.).
Apostolos John TsiourisDepartment of Radiology, Weill Cornell Medical College/New York-Presbyterian Hospital, New York, New York (P.P., H.B., A.J.T., A.G.); Samuel J. Wood Library & C. V. Starr Biomedical Information Center, Weill Cornell Medical College, New York, New York (D.D.); Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, New York (G.A., P.C.).
Ajay GuptaDepartment of Radiology, Weill Cornell Medical College/New York-Presbyterian Hospital, New York, New York (P.P., H.B., A.J.T., A.G.); Samuel J. Wood Library & C. V. Starr Biomedical Information Center, Weill Cornell Medical College, New York, New York (D.D.); Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, New York (G.A., P.C.).
Cornell University · USPresbyterian Hospital · USNew York Hospital Queens · USNewYork–Presbyterian Hospital · US

Funding

Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
NCATS NIH HHS UL1 TR000457
6 · The paper itself

Abstract

backgroundDistinction between tumor and treatment related changes is crucial for clinical management of patients with high-grade gliomas. Our purpose was to evaluate whether dynamic susceptibility contrast-enhanced (DSC) and dynamic contrast enhanced (DCE) perfusion-weighted imaging (PWI) metrics can effectively differentiate between recurrent tumor and posttreatment changes within the enhancing signal abnormality on conventional MRI.

methodsA comprehensive literature search was performed for studies evaluating PWI-based differentiation of recurrent tumor and posttreatment changes in patients with high-grade gliomas (World Health Organization grades III and IV). Only studies published in the "temozolomide era" beginning in 2005 were included. Summary estimates of diagnostic accuracy were obtained by using a random-effects model.

resultsOf 1581 abstracts screened, 28 articles were included. The pooled sensitivities and specificities of each study's best performing parameter were 90% and 88% (95% CI: 0.85-0.94; 0.83-0.92) and 89% and 85% (95% CI: 0.78-0.96; 0.77-0.91) for DSC and DCE, respectively. The pooled sensitivities and specificities for detecting tumor recurrence using the 2 most commonly evaluated parameters, mean relative cerebral blood volume (rCBV) (threshold range, 0.9-2.15) and maximum rCBV (threshold range, 1.49-3.1), were 88% and 88% (95% CI: 0.81-0.94; 0.78-0.95) and 93% and 76% (95% CI: 0.86-0.98; 0.66-0.85), respectively.

conclusionsPWI-derived thresholds separating viable tumor from treatment changes demonstrate relatively good accuracy in individual studies. However, because of significant variability in optimal reported thresholds and other limitations in the existing body of literature, further investigation and standardization is needed before implementing any particular quantitative PWI strategy across institutions.

Indexed as

Brain NeoplasmsCombined Modality TherapyContrast MediaGliomaHumansMagnetic Resonance AngiographyNeoplasm GradingPrognosisContrast Mediagliomasmeta-analysisMR perfusionpseudoprogressionradiation necrosis

Identifiers

PMID27502247
PMCPMC5193025
OpenAlexW2480178571

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.