SynthesisSleep & breathing = Schlaf & Atmung2017
Meta-analysis of all-cause and cardiovascular mortality in obstructive sleep apnea with or without continuous positive airway pressure treatment.
Synthesis in Sleep & breathing = Schlaf & Atmung, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06454318 (Screening Moderate to Severe Obstructive Sleep Apnea With Wearable Device), which is not on this map. Cited by 84 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Screening Moderate to Severe Obstructive Sleep Apnea With Wearable Device
Who cites it
84 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Positive airway pressure therapy and all-cause and cardiovascular mortality in people with obstructive sleep apnoea: a systematic review and meta-analysis of randomised controlled trials and confounder-adjusted, non-randomised controlled studies.The Lancet. Respiratory medicine · 2025Pooled it
- Are noradrenergics combined with antimuscarinics the future pharmacologic treatment for obstructive sleep apnea? A systematic review and meta-analysis of randomized controlled trials.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Effects of continuous positive airway pressure on cardiac events and metabolic components in patients with moderate to severe obstructive sleep apnea and coronary artery disease: a meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Pooled it
- The invisible costs of obstructive sleep apnea (OSA): Systematic review and cost-of-illness analysis.PloS one · 2022Pooled it
- European Respiratory Society guideline on non-CPAP therapies for obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2021Guideline
- Prevalence of obstructive sleep apnoea in acute coronary syndrome patients: systematic review and meta-analysis.BMC cardiovascular disorders · 2020Pooled it
- Effect of rhythm control on sleep disordered breathing in patients with atrial fibrillation or flutter: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2017Pooled it
- Clinical Use of a Home Sleep Apnea Test: An American Academy of Sleep Medicine Position Statement.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017Guideline
- Aroxybutynin and atomoxetine (AD109) for obstructive sleep apnea: a randomized phase 3 trial (SynAIRgy).American journal of respiratory and critical care medicine · 2026Trial
- Trial
- Long-term use of continuous positive airway pressure therapy in coronary artery disease patients with nonsleepy obstructive sleep apnea.Clinical cardiology · 2017Trial
- Effects of nocturnal intermittent hypoxia on metabolic syndrome in Japanese adults without abdominal obesity.International journal of obesity (2005) · 2026Article
- Article
- Gender differences in the psychosocial and functional impact of obstructive sleep apnea: findings from the SHINE patient survey.Sleep & breathing = Schlaf & Atmung · 2026Article
- Positive airway pressure therapy and cardiovascular events in obstructive sleep apnoea: an observational clinical cohort study.Sleep medicine · 2026Observational
- Temporal trends in mortality from pneumonia and obstructive sleep apnea in the United States (1999-2020): Insights from CDC WONDER.Medicine · 2026Article
- The association between obstructive sleep apnea and frailty traits: a bidirectional Mendelian randomization study.BMC pulmonary medicine · 2026Article
- Evaluating the relationship between obstructive sleep apnea and all-cause and cause-specific mortality in adults with and without metabolic syndrome using real-world data.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Patient Perspectives of a Sleep Apnea Treatment Adherence Intervention Adapted for Persons with Traumatic Brain Injury.Brain injury · 2025Article
- Exploring the Link Between Obstructive Sleep Apnea and Diabetes Mellitus: A Retrospective Single-Center Analysis.Biomedicines · 2025Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe associations between obstructive sleep apnea (OSA) and all-cause and cardiovascular mortality are well established but are not entirely consistent. To accurately evaluate these associations as well as the therapeutic effects of continuous positive airway pressure (CPAP), we conducted a comprehensive meta-analysis of all eligible cohort studies.
methodsElectronic literature databases (i.e., PubMed and Embase) were searched for relevant studies published before January 2016 that evaluated the associations between OSA and all-cause or cardiovascular mortality. Random-effect models were used to calculate the pooled hazard ratio (HR) and corresponding 95 % confidence intervals (CIs) for categorical risk estimates. The therapeutic effects of CPAP treatment for all-cause and cardiovascular mortality in OSA were examined through the meta-analysis.
resultsThe 27 cohort studies included in the meta-analysis included 3,162,083 participants. Compared to the control group, the pooled HR of all-cause mortality was 1.19 (95 % CI, 0.86-1.65) for mild OSA, 1.28 (0.96-1.69) for moderate OSA, and 2.13 (1.68-2.68) for severe OSA. The pooled HR of cardiovascular mortality was 1.24 (0.53-2.55) for mild OSA, 2.05 (0.57-5.47) for moderate OSA, and 2.73 (1.94-3.85) for severe OSA. All-cause mortality (HR 0.66; 0.59-0.73) and cardiovascular mortality (HR 0.37; 0.16-0.54) were significantly lower in CPAP-treated than in untreated patients. There were no differences in cardiovascular mortality in CPAP-treated OSA patients vs. normal control subjects (HR 0.82; 0.52-1.29).
conclusionsGreater attention should be paid to severe OSA, as it is an independent predictor for risk for all-cause and cardiovascular mortality. CPAP is an effective treatment that reduces risk of mortality.
Indexed as
Identifiers
27502205What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.