ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2017
Depression risk in patients with late-onset rheumatoid arthritis in Germany.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Elucidating the bidirectional association between autoimmune diseases and depression: a systematic review and meta-analysis.BMJ mental health · 2024Pooled it
- Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Trends in Anxiety and Depression Among Individuals With Rheumatoid Arthritis: A Population-Based Study.The Journal of rheumatology · 2025Article
- Rheumatoid Arthritis and Risk of Depression in South Korea.JAMA network open · 2024Article
- Biological factors influencing depression in later life: role of aging processes and treatment implications.Translational psychiatry · 2023Review
- Unusual presentation of rheumatoid arthritis in a 106-year-old woman: A rare case report.Clinical case reports · 2023Article
- [Higher prevalence of depressive and anxiety symptoms in early arthritis patients in comparison to the normal population].Zeitschrift fur Rheumatologie · 2019Article
- Prevalence of comorbidities and their associations with health-related quality of life and healthcare expenditures in patients with rheumatoid arthritis.Clinical rheumatology · 2019Article
- Persistence and treatment-free interval in patients being prescribed biological drugs in rheumatology practices in Germany.European journal of clinical pharmacology · 2019Article
- Management of inflammatory rheumatic conditions in the elderly.Rheumatology (Oxford, England) · 2019Review
- Persistence with biological drugs in patients treated in rheumatology practices in Germany.Rheumatology international · 2019Article
- Long-term use of benzodiazepines in older patients in Germany: a retrospective analysis.Therapeutic advances in psychopharmacology · 2017Article
- Prevalence of depression, anxiety, adjustment disorders, and somatoform disorders in patients with age-related macular degeneration in Germany.German medical science : GMS e-journal · 2017Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
goalThe goal of this study was to determine the prevalence of depression and its risk factors in patients with late-onset rheumatoid arthritis (RA) treated in German primary care practices.
methodsLongitudinal data from general practices (n=1072) throughout Germany were analyzed. Individuals initially diagnosed with RA (2009-2013) were identified, and 7301 patients were included and matched (1:1) to 7301 controls. The primary outcome measure was the initial diagnosis of depression within 5 years after the index date in patients with and without RA. Cox proportional hazards models were used to adjust for confounders.
resultsThe mean age was 72.2 years (SD: 7.6 years). A total of 34.9 % of patients were men. Depression diagnoses were present in 22.0 % of the RA group and 14.3 % of the control group after a 5-year follow-up period (p < 0.001). In the multivariate regression model, RA was a strong risk factor for the development of depression (HR: 1.55, p < 0.001). There was significant interaction of RA and diagnosed inflammatory polyarthropathies (IP) (RA*IP interaction: p < 0.001). Furthermore, dementia, cancer, osteoporosis, hypertension, and diabetes were associated with a higher risk of developing depression (p values <0.001).
conclusionThe risk of depression is significantly higher in patients with late-onset RA than in patients without RA for subjects treated in primary care practices in Germany. RA patients should be screened routinely for depression in order to ensure improved treatment and management.
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