ArticleNature chemical biology2016
A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival.
Article in Nature chemical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Stereoselective Synthesis and Antiproliferative Activity of Nemamide Analogs.Journal of natural products · 2025Article
- The Role of Nucleotide Sequencing in Natural Product Drug Discovery.Journal of natural products · 2025Review
- Characterizing the Biochemical Role of an Unusual Fatty Acyl-AMP Ligase from a Hybrid PKS-NRPS Pathway in Nematodes.ACS chemical biology · 2025Article
- Animal-Encoded Nonribosomal Pathway to Bursatellin Analogs.Journal of the American Chemical Society · 2025Article
- Discovery of a parallel family of euglenatide analogs in Euglena gracilis.Natural products and bioprospecting · 2025Article
- Chromosome-level genome assembly of the sacoglossan sea slug Elysia timida (Risso, 1818).BMC genomics · 2024Article
- Synthesis of Simplified 2-Desmethyl Sanctolide A Analogs.The Journal of organic chemistry · 2024Article
- Bdelloid rotifers deploy horizontally acquired biosynthetic genes against a fungal pathogen.Nature communications · 2024Article
- A niche-derived nonribosomal peptide triggers planarian sexual development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- NRPS-like ATRR in Plant-Parasitic Nematodes Involved in Glycine Betaine Metabolism to Promote Parasitism.International journal of molecular sciences · 2024Article
- The polyketide to fatty acid transition in the evolution of animal lipid metabolism.Nature communications · 2024Article
- A niche-derived non-ribosomal peptide triggers planarian sexual development.bioRxiv : the preprint server for biology · 2023Article
- Nonribosomal Peptide Synthetases in Animals.Genes · 2023Review
- Genomic mining and diversity of assembly line polyketide synthases.Open biology · 2023Article
- Repurposing degradation pathways for modular metabolite biosynthesis in nematodes.Nature chemical biology · 2023Review
- Total Synthesis of Sanctolide A and Formal Synthesis of (2The Journal of organic chemistry · 2023Article
- Sex-specificity of the C. elegans metabolome.Nature communications · 2023Article
- Brain-wide bidirectional neuropeptide modulation of individual neuron classes regulates a developmental decision.Current biology : CB · 2022Article
- A single amino acid residue controls acyltransferase activity in a polyketide synthase fromiScience · 2022Article
- Euglenatides, Potent Antiproliferative Cyclic Peptides Isolated from the Freshwater Photosynthetic Microalga Euglena gracilis.Angewandte Chemie (International ed. in English) · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
Polyketides and nonribosomal peptides are two important types of natural products that are produced by many species of bacteria and fungi but are exceedingly rare in metazoans. Here, we elucidate the structure of a hybrid polyketide-nonribosomal peptide from Caenorhabditis elegans that is produced in the canal-associated neurons (CANs) and promotes survival during starvation-induced larval arrest. Our results uncover a novel mechanism by which animals respond to nutrient fluctuations to extend survival.
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Registered trials
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